Results 251 to 260 of about 234,095 (317)

Structure‐Based Development of Ultra‐Broad‐Spectrum 3C‐Like Protease Inhibitors

Advanced Science, EarlyView.
This study provides an in‐depth analysis of the substrate binding pocket of 3CLpros across all coronavirus species using bioinformatics and structural insights, revealing the critical impact of S2/S4 subsite diversity on the broad‐spectrum activity of approved therapeutics.
Haixia Su, Tianqing Nie, Guofeng Chen, Muya Xiong, Yumin Zhang, Guoqing Wu, Mengyuan You, Hang Xie, Jian He, Yanchao Xiong, Hangchen Hu, Wenfeng Zhao, Minjun Li, Gengfu Xiao, Leike Zhang, Yechun Xu   +15 more
wiley   +1 more source

AP Model: A Simple Tool to Predict Poor Long-Term PAP Adherence in Obstructive Sleep Apnea. [PDF]

OTO Open
Tawaranurak K, Kongtawee P, Nilrat N.
europepmc   +1 more source

CLinNET: An Interpretable and Uncertainty‐Aware Deep Learning Framework for Multi‐Modal Clinical Genomics

Advanced Science, EarlyView.
Identifying disease‐causing genes in neurocognitive disorders remains challenging due to variants of uncertain significance. CLinNET employs dual‐branch neural networks integrating Reactome pathways and Gene Ontology terms to provide pathway‐level interpretability of genomic alterations.
Ivan Bakhshayeshi, Mohammad Mahdi Hosseini, Ahmadreza Argha, Roxana Zahedi, Nigel H. Lovell, Hamid Alinejad‐Rokny   +5 more
wiley   +1 more source

Hemorrhoids and cardiovascular disease: A bidirectional Mendelian randomization study. [PDF]

Open Med (Wars)
Ge X, Tang W, Ni J.
europepmc   +1 more source

AAPM working group on cybersecurity report 438: A white paper on cybersecurity management for business continuity in radiology and radiation therapy. [PDF]

J Appl Clin Med Phys
Siochi RA, Balter P, Hedrick S, Howe J, Ma T, Soisson E, Yung J, Curran B.   +7 more
europepmc   +1 more source

Comparative Systematic Review of Telehealth Delivery Models, Intervention Content, and Outcomes in Heart Failure Care. [PDF]

Patient Prefer Adherence
Sugiharto F, Trisyani Y, Nuraeni A, Abdullah KL.   +3 more
europepmc   +1 more source

Non-invasive respiratory support in pediatric patients with acute hypoxemic respiratory failure: a systematic review and network meta-analysis of randomized controlled trials. [PDF]

EClinicalMedicine
Feng Y, Wang J, Yin Y, Florez ID, Li Y, Estill J, Ozaki A, Wang X, Hara A, Tao Z, Shao W, Wu Z, Ge L, Chen Y.   +13 more
europepmc   +1 more source

Is hyperoxia during veno-arterial extracorporeal life support due to cardiopulmonary failure associated with mortality in pediatric patients? [PDF]

J Extra Corpor Technol
Beshish AG, Shamah R, Qian J, Keane-Lerner K, Morales PR, Zinyandu T, Davis J, Rosenblum JM, Viamonte HK.   +8 more
europepmc   +1 more source