Results 51 to 60 of about 233,659 (210)

Using the Failure Mode and Effect Analysis Tool to Improve the Automatic Stop Order Process [PDF]

Global Journal on Quality and Safety in Healthcare
Introduction Automatic stop orders (ASOs) in computerized prescription order entry (CPOE) systems predefine the length of treatment. This can improve resource use for select therapies (e.g., empirical antibiotics).
Ghada Hussain Al Mardawi, Rajkumar Rajendram, Arwa Balharith, Abdulaziz Alomaim   +3 more
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Escaping the Shadow of Malpractice Law [PDF]

, 2011
Abinovich-Einy addresses several constituencies operating at the meeting point of alternative dispute resolution (ADR), communication theory, healthcare policy, and medical-malpractice doctrine.
Rabinovich-Einy, Orna
core   +1 more source

Strategy Workshops and Strategic Change [PDF]

, 2008
Despite the attention that strategic change as a topic of research has received, there remain considerable difficulties in conceptualizing the actual sources of strategic change.
MacIntosh, Robert, MacLean, Donald, Seidl, David   +2 more
core   +2 more sources

Nursing and euthanasia : a narrative review of the nursing ethics literature [PDF]

, 2020
Background: Medical Assistance in Dying, also known as euthanasia or assisted suicide, is expanding internationally. Canada is the first country to permit Nurse Practitioners to provide euthanasia.
Burgess, Michael, Chambaere, Kenneth, Greig, Madeleine, Janke, Robert, Pesut, Barbara, Storch, Janet, Thorne, Sally, Tishelman, Carol   +7 more
core   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Prognostic value of echocardiographic indices of left atrial morphology and function in dogs with myxomatous mitral valve disease [PDF]

, 2018
Background: The prognostic relevance of left atrial (LA) morphological and functional variables, including those derived from speckle tracking echocardiography (STE), has been little investigated in veterinary medicine.
Baron Toaldo, Marco, Cipone, Mario, Contiero, Barbara, Diana, Alessia, Guglielmini, Carlo, Pelle, Nazzareno G., Romito, Giovanni   +6 more
core   +2 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Improving patient safety during intrahospital transportation of mechanically ventilated patients with critical illness

BMJ Open Quality, 2020
Aim Intrahospital transportation (IHT) of patients under mechanical ventilation (MV) significantly increases the risk of patient harm. A structured process performed by a well-prepared team with adequate communication among team members plays a vital ...
Jih-Shuin Jerng, Shwu-Jen Lin, Chin-Yuan Tsan, Mao-Yuan Su, Chao-Ling Wu, Li-Chin Chen, Hsiu-Jung Hsieh, Wei-Ling Hsiao, Jui-Chen Cheng, Yao-Wen Kuo, Huey-Dong Wu, Jui-Sheng Sun   +11 more
doaj   +1 more source