Results 71 to 80 of about 234,095 (317)

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

A Proactive Risk Assessment Through Healthcare Failure Mode and Effect Analysis in Pediatric Surgery Department

Journal of Comprehensive Pediatrics, 2020
Background: Patient safety is the first step to improve the quality of care. Objectives: Therefore, the present study aimed to examine the risk assessment of processes in a pediatric surgery department using the Health Failure Mode and Effect Analysis (HFMEA) in 2017 - 2018.
Yasamin Molavi-Taleghani, Hossein Ebrahimpour, Hojjat Sheikhbardsiri   +2 more
openaire   +2 more sources

Using healthcare failure mode and effect analysis as a method of vaginal birth after caesarean section management [PDF]

Journal of Clinical Nursing, 2019
AbstractAims and objectivesThis research was conducted to explore the effectiveness of employing the healthcare failure mode and effect analysis method in the management of trial of labour after caesarean, with the aims of increasing vaginal birth after caesarean section rate and reducing potential risks that might cause severe complications ...
Ying Liu, Wei Zhu, Shiguan Le, Wenxian Wu, Qun Huang, Weiwei Cheng   +5 more
openaire   +2 more sources

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

A Hybrid FMEA-ROC-CoCoSo Approach for Improved Risk Assessment and Reduced Complexity in Failure Mode Prioritization

Algorithms
This paper proposes a novel hybrid model that integrates failure mode and effects analysis (FMEA), Rank Order Centroid (ROC), and Combined Compromise Solution (CoCoSo) to improve risk assessment and prioritization of failure modes.
Vitor Anes, António Abreu
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Myocardial creatine levels do not influence response to acute oxidative stress in isolated perfused heart [PDF]

, 2014
Background: Multiple studies suggest creatine mediates anti-oxidant activity in addition to its established role in cellular energy metabolism.
Aksentijević, Dunja, Faller, Kiterie M.E., Lygate, Craig A., McAndrew, Debra J., Neubauer, Stefan, Schneider, Jurgen E., Zazueta, Cecilia, Zervou, Sevasti   +7 more
core   +2 more sources

Healthcare failure mode and effect analysis (HFMEA) for improving the qualification rate of disinfection quality monitoring process

Journal of Infection and Public Health, 2020
This study aimed to assess potential failure mode, implement countermeasures against risks and improve disinfection quality monitoring using healthcare failure mode and effect analysis (HFMEA).Between July 2017 and March 2018, a multidisciplinary team was formed to conduct HFMEA and implement improvement interventions.
Xuxia Yu, Tieer Gan, Yuexian Zhu, Junmin Cao, Xuejing Yang, Bo Jin, Ying Zhang, Weijiang Zhan   +7 more
openaire   +3 more sources

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Norton Healthcare: A Strong Payer-Provider Partnership for the Journey to Accountable Care [PDF]

, 2012
Examines the progress of an integrated healthcare delivery system in forming an accountable care organization with payer partners as part of the Brookings-Dartmouth ACO Pilot Program, including a focus on performance measurement and ...
Aricca D. Van Citters, Bridget K. Larson, Elliott S. Fisher, Eugene C. Nelson, Josette N. Gbemudu, Sara A. Kreindler, Stephen M. Shortell   +6 more
core