Results 101 to 110 of about 627,738 (287)

E-infrastructures fostering multi-centre collaborative research into the intensive care management of patients with brain injury [PDF]

, 2009
Clinical research is becoming ever more collaborative with multi-centre trials now a common practice. With this in mind, never has it been more important to have secure access to data and, in so doing, tackle the challenges of inter-organisational data ...
Piper, I., Sinnott, R.O.
core  

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

CHRONIC RECURRENT MULTIFOCAL OSTEOMYELITIS: CASE REPORT

Žurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta, 2017
The article presents a clinical case of chronic recurrent multifocal osteomyelitis in a child (the girl aged 11 years old). Clinical manifestations, data of laboratory and instrumental examinations, treatment of the above disease are described. Good
Khotsim O. A., Sychevskiy L. Z., Anosov V. S.   +2 more
doaj   +1 more source

Automated CT and MRI Liver Segmentation and Biometry Using a Generalized Convolutional Neural Network. [PDF]

, 2019
PurposeTo assess feasibility of training a convolutional neural network (CNN) to automate liver segmentation across different imaging modalities and techniques used in clinical practice and apply this to enable automation of liver biometry.MethodsWe ...
Bahrami, Naeim, Bass, Emily, Blansit, Kevin, Cunha, Guilherme, Delgado, Timoteo, Hasenstab, Kyle, Hsiao, Albert, Loomba, Rohit, Mamidipalli, Adrija, members of the NASH Clinical Research Network, Middleton, Michael S, Neuschwander-Tetri, Brent A, Retson, Tara, Sirlin, Claude B, Wang, Kang   +14 more
core  

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Analysis of incidence and prevalence of the respiratory system diseases of the adult population of Moscow and the Russian Federation

Здоровье мегаполиса, 2022
Introduction. As a result of the COVID-19 pandemic that swept the whole world in 2020, the level and structure of morbidity changed, the “center of gravity” of adult mortality shifted towards infectious diseases.
V. M. Kuraeva, S. I. Feiginova, А. М. Podchernina   +2 more
doaj  

Enteroviral Meningitis: Peculiarities of the Course and Diagnosis at the Present Stage

Zdorovʹe Rebenka, 2016
Background. Enteroviral infection is characterized by a variety of clinical forms: non-specific enterovirus fever, herpangina, hand-foot-and-mouth disease, pleurodynia, meningitis, gastroenteritis, nonspecific enteroviral rash.
L.R. Shostakovych-Koretskaya, V.G. Slatvitsky, I.V. Budayeva, Z.O. Chykarenko, L.M. Cherhinets, V.O. Ulianov, O.Y. Lyahova   +6 more
doaj   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

SmallTalk: a novel small‐sized fusion tag for peptide expression and purification

FEBS Open Bio, EarlyView.
The SmallTalk fusion tag allows for the efficient expression and purification of soluble recombinant proteins or peptides in Escherichia coli. Testing with SmallTalk‐GFP confirmed that the proteins were soluble and folded correctly, while SmallTalk‐Bin1b maintained its antimicrobial activity against various bacterial isolates. This streamlined workflow
Atika Tariq, Nestor G. Casillas‐Vega, Alma Gomez‐Loredo, Xristo Zarate   +3 more
wiley   +1 more source

Successful endoscopic treatment of diverticular disease complicated by paracolic abscess

Российский журнал гастроэнтерологии, гепатологии, колопроктологии, 2018
Aim of clinical case presentation. To evaluate potential of intraluminal endoscopy for the treatment of diverticulitis, complicated by paracolic abscess. Summary. The clinical case of complicated colonic diverticula treatment by intraluminal endoscopy is
A. I. Khripun, G. B. Makhuova, A. A. Izvekov, M. V. Monakhov   +3 more
doaj   +1 more source