Results 41 to 50 of about 388,212 (312)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Level of Partograph completion and healthcare workers’ perspectives on its use in Mulago National Referral and teaching hospital, Kampala, Uganda

BMC Health Services Research, 2019
Background The appropriate use of the Partograph allows early identification of labour related complications and prevents deaths. We, therefore, sought to determine the level of Partograph completion and healthcare worker perspectives towards its ...
John Mukisa, Isha Grant, Jonathan Magala, Andrew S. Ssemata, Patrick Z. Lumala, Josaphat Byamugisha   +5 more
doaj   +1 more source

Post-acute COVID-19 syndrome after reinfection and vaccine breakthrough by the SARS-CoV-2 Gamma variant in Brazil

International Journal of Infectious Diseases, 2022
We describe a case of prolonged COVID-19 caused by the SARS-CoV-2 Gamma variant in a fully vaccinated healthcare worker, 387 days after an infection caused by lineage B.1.1.33.
Stephanie L.S. Penetra, Michele F.B. da Silva, Paola Resende, Anielle Pina-Costa, Heloisa F.P. Santos, Lusiele Guaraldo, Guilherme A. Calvet, Maria Ogrzewalska, Ighor Arantes, Ketiuce Zukeram, Mia F. de Araújo, Ana Beatriz Machado Lima, Renata Serrano Lopes, Larissa R. Lira-Silva, Isabella V. Moraes, Mayumi D. Wakimoto, Trevon L. Fuller, Claudia Raja Gabaglia, Otávio M. Espíndola, Myrna C. Bonaldo, Cláudio Tadeu Daniel-Ribeiro, Jimmy Whitworth, Chris Smith, Karin Nielsen-Saines, Alex Pauvolid-Correa, Marilda M. Siqueira, Patricia Brasil   +26 more
doaj   +1 more source

Conflict management system in health care [PDF]

Health Economics and Management Review, 2020
This article provides ways to improve the conflict management system in health care based on analyzing the causes of conflicts in a private medical institution. The authors considered the healthcare delivery process in the triad «health worker - patient –
Tetiana Tenytska, Iuliia Myroshnychenko, Ekaterine Lomia   +2 more
doaj   +1 more source

Children's Medicines in Tanzania: A National Survey of Administration Practices and Preferences. [PDF]

, 2013
The dearth of age-appropriate formulations of many medicines for children poses a major challenge to pediatric therapeutic practice, adherence, and health care delivery worldwide.
AN Sachs, Cameron T. Nutt, D Baguley, D Notterman, DC Knoppert, DM Taylor, E Ansah, Elia John Mmbaga, G Peacock, Gary J. Noel, H Zucker, Helga Naburi, Imti Choonara, J Breitkreutz, J Teng, JA Mennella, K Hoppu, K Hoppu, K Hoppu, Lisa V. Adams, M Gazarian, P Nahirya-Ntege, Rodrick Kisenge, S Beggs, S Hill, S MacLeod, Sienna R. Craig, SR Craig, SR Hill, Stephen P. Spielberg, T Nunn, Timothy Lahey, W Rodriguez   +32 more
core   +3 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Inter-professional collaboration reduces the burden of caring for patients with mental illnesses in primary healthcare. A realist evaluation study [PDF]

, 2019
Background:The implementation of primary care for mental health is often insufficient, whichleaves its mark on staff. A team-based approach of mental healthcare prevents poor staff mor-ale.
De Sutter, An, De Sutter, Marieke, Decat, Peter, Declercq, Tom, Sundahl, Nora   +4 more
core   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Disseminated tuberculosis in a pregnant immunocompetent healthcare worker

Egyptian Journal of Chest Disease and Tuberculosis, 2020
Health care workers (HCWs) have an increased risk of Mycobacterium Tuberculosis (TB) infection compared to general population. Pregnancy suppresses the Lymphocyte T-helper 1 (Th1) pro-inflammatory response.
Mersni Meriem, Mechergui Najla, Belloumi Nidhal, Bani Mejda, Ladhari Nizar, Youssef Imen   +5 more
doaj   +1 more source

Healthcare Workers in Peril: Preparing to Protect Worker Health and Safety During Pandemic Influenza [PDF]

, 2009
[Excerpt] An influenza pandemic is projected to have a global impact requiring a sustained, large scale response from the healthcare community to provide care to sick patients. Healthcare workers will be at very high risk of becoming infected when caring
AFL-CIO
core   +1 more source