Results 171 to 180 of about 91,653 (266)

Exposing Deficit Discourse in Aboriginal and Torres Strait Islander Peoples' Ageing Policy: Promoting Healthy Ageing for Our Elders. [PDF]

Australas J Ageing
Howell N, Stuart L.
europepmc   +1 more source

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

Definition and conceptual framework of the psychological domain of intrinsic capacity in healthy ageing: outcomes from the MOSAIC International Working Group. [PDF]

J Nutr Health Aging
Hagani N, Windle A, Oster C, Hines S, Khadka J, Isaac V.   +5 more
europepmc   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Equity and healthy ageing

Bulletin of the World Health Organization, 2017
Venkatapuram, Sridhar, Ehni, Hans Jörg, Saxena, Abha   +2 more
openaire   +3 more sources

Posttrial Withdrawal Ethics in the Healthy Ageing Ecosystem for People With Dementia (HAAL) Study. [PDF]

JMIR Res Protoc
Johny P, Kr A.
europepmc   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Correction to: Socio‑economic position and healthy ageing across the life course: a systematic review of longitudinal studies. [PDF]

Geroscience
Ye Y, Long C, Chua KC, Moreno-Agostino D, Prina M.   +4 more
europepmc   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Authors' Reply: Posttrial Withdrawal Ethics in the Healthy Ageing Ecosystem for People With Dementia (HAAL) Study. [PDF]

JMIR Res Protoc
Amabili G, Maranesi E, Barbarossa F, Margaritini A, Bonfigli AR, Su FC, Lin CJ, Chieh HF, Vasseur D, Nap HH, Hsu YL, Bai D, Bevilacqua R.   +12 more
europepmc   +1 more source