Results 191 to 200 of about 960,492 (356)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Analysis of comparisons of eating-out, dietary lifestyles, and healthy dietary competencies among middle-aged consumers according to obesity status and gender for implications of consumer education

, 2018
Jong Ok Park
openalex   +1 more source

P3‐406: PET imaging of amyloid burden and cognitive assessment for the reliable discrimination between healthy aging, subjective memory impairment and mild cognitive impairment [PDF]

, 2012
Peter J. Snyder, David Darby, Yen Ying Lim, Amy Fredrickson, Robert H. Pietrzak, Christopher C. Rowe, Victor L. Villemagne, Paul Maruff   +7 more
openalex   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Therapeutic peptides in gerontology: mechanisms and applications for healthy aging. [PDF]

Front Aging
Mavrych V, Shypilova I, Bolgova O.
europepmc   +1 more source

Financing Healthy Aging in India: A Hybrid Social Health Insurance Framework for Long-Term Care

Amith Sunny Aranha
openalex   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Author Correction: Identification of KIFC1 as an independent prognostic marker in renal clear cell carcinoma correlates with tumor proliferation and immune infiltration

Scientific Reports
Bin Du, Jia Wang, Jinping Zheng, Jing Huo, Pu Wang   +4 more
doaj   +1 more source

Evidence-based interventions for promoting healthy aging: a scoping review. [PDF]

J Nutr Health Aging
González-Ballesteros LM, Mojica LE, Riveros S, Zamora VV, Gómez A, Otero Rueda MDP, Chaves Matiz F, Jaimes Velásquez MA, López V, Ramírez L, Sánchez Herrera V.   +10 more
europepmc   +1 more source

Spontaneous fractures in healthy postmenopausal women aged 55+ years in two health centers: Laquintinie Hospital and General Hospital, Douala, Cameroon [PDF]

Aline BAMIA, Rama Natacha SONGUE, Andréa ADIOGO, Sebastien OMBOTO, Dieudonné Adiogo   +4 more
openalex   +1 more source