Results 91 to 100 of about 3,703,784 (349)

Investigating the Status of Healthy Nutrition Index, Fat, Cholesterol and Sodium Intake in Residents Over 19 Years of Age in Yasuj, Iran, in 2020 [PDF]

Armaghane Danesh Bimonthly Journal, 2023
Background & aim: Unhealthy diet - as one of the main risk factors of non-communicable diseases and responsible for most chronic diseases and their mortality, which affects people's health regardless of age, gender and social cultural conditions.
JM Malekzadeh, A Pourmahmoudi, F Mohammadi Nia   +2 more
doaj  

A CCL2+DPP4+ subset of mesenchymal stem cells expedites aberrant formation of creeping fat in humans

Nature Communications, 2023
Creeping fat is a typical feature of Crohn’s disease. It refers to the expansion of mesenteric adipose tissue around inflamed and fibrotic intestines and is associated with stricture formation and intestinal obstruction.
Fengfei Wu, Fangting Wu, Qian Zhou, Xi Liu, Jieying Fei, Da Zhang, Weidong Wang, Yi Tao, Yubing Lin, Qiaoqiao Lin, Xinghua Pan, Kai Sun, Fang Xie, Lan Bai   +13 more
doaj   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Relationship between maximal fat oxidation and oxygen uptake: comparison between type 2 diabetes patients and healthy sedentary subjects

Journal of Biological Research, 2014
The contribution of fat oxidation to energy production during exercise is influenced by intensity of exercise. The aim of this study was to assess the relationship between the highest value of fat oxidation rate (FATmax) and the oxygen uptake (VO2) in ...
Angelo Cataldo, Giuseppe Russo, Dario Cerasola, Danila Di Majo, Marco Giammanco, Marcello Traina   +5 more
doaj   +1 more source

Adolescent dietary patterns are associated with lifestyle family psycho-social factors [PDF]

, 2009
Background/ Objectives: Dietary intake during adolescence contributes to lifelong eating habits and the development of early risk factors for disease in adulthood.
Ambrosini, Gina L, Beilin, Lawrence, de Klerk, Nick H, Hands, Beth P, Kendall, Garth E, O\u27Sullivan, Therese A, Oddy, Wendy H, Robinson, Monique, Silburn, Sven, Stanley, Fiona, Zubrick, Stephen R   +10 more
core   +2 more sources

The Metabolic Phenotype in Obesity: Fat Mass, Body Fat Distribution, and Adipose Tissue Function

Obesity Facts, 2017
The current obesity epidemic poses a major public health issue since obesity predisposes towards several chronic diseases. BMI and total adiposity are positively correlated with cardiometabolic disease risk at the population level.
G. Goossens
semanticscholar   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Regional adipose distribution and metabolically unhealthy phenotype in Chinese adults: evidence from China National Health Survey

Environmental Health and Preventive Medicine
Background: The mechanisms distinguishing metabolically healthy from unhealthy phenotypes within the same BMI categories remain unclear. This study aimed to investigate the associations between regional fat distribution and metabolically unhealthy ...
Binbin Lin, Yaoda Hu, Huijing He, Xingming Chen, Qiong Ou, Yawen Liu, Tan Xu, Ji Tu, Ang Li, Qihang Liu, Tianshu Xi, Zhiming Lu, Weihao Wang, Haibo Huang, Da Xu, Zhili Chen, Zichao Wang, Guangliang Shan   +17 more
doaj   +1 more source

Prior Consumption of a Fat Meal in Healthy Adults Modulates the Brain’s Response to Fat [PDF]

The Journal of Nutrition, 2016
The consumption of fat is regulated by reward and homeostatic pathways, but no studies to our knowledge have examined the role of high-fat meal (HFM) intake on subsequent brain activation to oral stimuli.We evaluated how prior consumption of an HFM or water load (WL) modulates reward, homeostatic, and taste brain responses to the subsequent delivery of
Eldeghaidy, Sally, Marciani, Luca, Hort, Joanne, Hollowood, Tracey Ann, Singh, Gulzar, Bush, Debbie, Foster, Tim, Taylor, Andrew J., Busch, Johanneke, Spiller, Robin C., Gowland, Penny A., Francis, Susan T.   +11 more
openaire   +3 more sources

A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy

Molecular Oncology, EarlyView.
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti, Giovanni Germano, Pietro Paolo Vitiello, Alberto Bardelli   +3 more
wiley   +1 more source