Results 91 to 100 of about 1,153,162 (300)
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Matrik, 2019 The purposes of the research are to analyzing, evaluating, and measuring the correlation between employee's perception of Germas (healthy life movement) on the behaviour of healthy living in the work environment, according to the recommendations in ...
Regina Nova Indradewi +2 more
doaj +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Journal of PharmacyIntroduction: Home Medication Review (HMR) is crucial for optimising medication use and improving patient’s outcomes. Despite its potential benefits, HMR implementation in rural areas faces challenges.
Norny Syafinaz Ab Rahman +2 more
doaj
Jurnal Ilmiah KesehatanMalaria is a tropical disease caused by the bite of the Anopheles mosquito. Malaria is an infectious disease that is of global concern. This disease still often causes extraordinary events.
Rusni +3 more
doaj +1 more source
THE HEALTHY CITY: PHYSICAL PLANNING TOWARDS SUSTAINABLE URBAN DEVELOPMENT [PDF]
, 2009 Urbanization in Indonesia has been growing rapidly, and is expected to accelerate in the future. It is envisaged that the urban population of the country will grow from 54.7% in 1995 to about 73% I the year 2020.
Yuliastuty, Nany
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Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Every chance for every child [PDF]
This policy discussion paper has been developed in response to extensive social research indicating that education, employment, healthy living conditions and social support networks all have a very strong influence on families’ ability to provide the ...
core
Green Housing = Improved Health: A Winning Combination [PDF]
, 2011 The case studies in this paper explore the relationship between housing and health. It explains how building affordable green housing provides health benefits to low-income residentsand it identifies the benefits of green housing for the environment and ...
Noreen Beatley
core
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source