Results 181 to 190 of about 7,505,655 (284)

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

The 'active reciprocity' ecosystem: senior cohousing as a determinant of social support and cognitive vitality independent of socioeconomic status. [PDF]

Front Public Health
Delgado-Losada ML, Sequeira-Villatoro B, Alcaide-Prieto C, Bouhaben J, Delgado-Ramos A.   +4 more
europepmc   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Associations between food deserts, food swamps, and ultra-processed food intake in childhood. [PDF]

Rev Paul Pediatr
Torre ACDCD, Milbratz BA, Segheto W, Toloni MHA, Lima DB.   +4 more
europepmc   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Editorial: Shaping cities for health: built environment, active living, and well-being

Frontiers in Sports and Active Living
Kaichen Zhou, Izzy Yi Jian, Xiji Jiang
doaj   +1 more source

Interviews of community-dwelling older persons in Greece on healthy aging and wellbeing during multiple crises (the HAiG study). [PDF]

Front Aging
Mallidou AA, Zioga E, Magripi A, Roditi E, Provida FD, Apostolidi TP, Papathanasiou IV, Sourtzi P.   +7 more
europepmc   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Some explorations about extending the right to a healthy environment to future generations and animals

The right to a healthy environment has not yet unveiled all its dimensions. In this chapter we analyse the right to a healthy environment of future generations and animals.
Schoukens, HendrikeditorRE220020053416248020001842350000-0002-5163-573001754BF8-F0EE-11E1-A9DE-61C894A0A6B4, Verniers, ElienRE220001201690548020023475370000-0001-9417-2230037E9660-F0EF-11E1-A197-91C894A0A6B4, Van Hoorick, GeertRE228010008655790000-0002-1111-3591F4A3C774-F0ED-11E1-A9DE-61C894A0A6B4, Bouquelle, FaraheditorRE22001999379659801002014223CF503EDC-95D6-11E8-9228-8B155707D3EF   +3 more
core  

The role of dog keeping in the home microbiota and its impact on children's health. [PDF]

Pediatr Allergy Immunol
Mäki JM, Kirjavainen PV, Täubel M, Tuoresmäki P, Piippo-Savolainen E, Backman K, Pekkanen J, Karvonen AM.   +7 more
europepmc   +1 more source