Results 31 to 40 of about 243,132 (253)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Healing of Air—Embodied Interaction and Contextual Healing Experience Mechanism in Residential Air Environment

Buildings
The modern high-pressure lifestyle has led to an increasing emphasis on the healing construction of residential spaces, while air, as an important environmental factor, has received little attention in terms of situational healing experiences within the ...
Yanni Cai, Duan Wu, Hongtao Zhou
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Private space open to the public as an addition to the urban public space network [PDF]

Urbani Izziv, 2012
One of the most important priorities of (sustainable) urban planning is to ensure the quality of life and a healthy living environment. Both are primarily regulated as part of the public space network – that is, in city parks, squares, streets, forests ...
Liljana Jankovič Grobelšek
doaj  

Study protocol: healthy urban living and ageing in place (HULAP): an international, mixed methods study examining the associations between physical activity, built and social environments for older adults the UK and Brazil

BMC Public Health, 2018
Background The ability to ‘age in place’ is dependent on a range of inter-personal, social and built environment attributes, with the latter being a key area for potential intervention.
Geraint Ellis, Ruth F. Hunter, Adriano Akira F. Hino, Claire L. Cleland, Sara Ferguson, Brendan Murtagh, Ciro Romelio Rodriguez Anez, Sara Melo, Mark Tully, Frank Kee, Urmi Sengupta, Rodrigo Reis   +11 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Eco living – An effective interior spatial planning as an intervention towards healthy living environment

IOP Conference Series: Earth and Environmental Science, 2023
Abstract Healthy housing is a fundamental element for healthy community. It ensures the availability of safe, decent, and affordable housing that supports the health of its occupants. In addition, people spend more than 80% of their time inside the house.
Siti Nuratirah Che Mohd Nasir, W Omar Ali Saifudin Wan Ismail, Salmiah Aziz, Nor Hafizah Anuar, Najah Md Alwi, Noorul Huda Mohd Razali   +5 more
openaire   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source