Results 101 to 110 of about 9,426,984 (278)

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Editorial: The built environment and public health: New insights

Frontiers in Public Health, 2023
Linchuan Yang, Ruoyu Wang, Baojie He, Yu Ye, Yibin Ao   +4 more
doaj   +1 more source

Healthy parks, healthy people, healthy tourism : the application of the ASEAN Healthy Tourism Standard to address the emerging threats from tourism at Ha Long Bay World Heritage Site, Vietnam

, 2010
This paper explores problems associated with the impacts of tourism on the health of people and the environment. ASEAN through UWS is developing the concept of ‘Healthy Tourism’ to protect and promote the health of tourists and local communities to turn ...
Bushell, Robyn (R7359), Powis, Brent
core  

Healthy ageing and home: The perspectives of very old people in five European countries [PDF]

, 2014
This paper reports on in-depth research, using a grounded theory approach, to examine the ways in which very old people perceive healthy ageing in the context of living alone at home within urban settings in five European countries.
Fange, A, Tomsone, S, TOMSONE Signe, Woolrych, R., WOOLRYCH Ryan, Sixsmith, Andrew, Dahlin-Ivanoff, Sylvia, Naumann, D., Woolrych, Ryan, Dahlin-Ivanoff, Synneve,, SIXSMITH Andrew, Dahlin-Ivanoff, Synneve, Sixsmith, Judith, KUCSERA Csaba, Fänge Malmgren, Agneta, NAUMANN Dörte, Sixsmith, J.; id_orcid, Sixsmith, A., Dahlin-Ivanoff, S., Kucsera, Csaba, Dahlin-Ivanoff, S, Kucsera, C., Woolrych, R, Naumann, Dorte, Sixsmith, A, Kucsera, C, DAHLIN-IVANOFF Synneve, Tomsone, S., Malmgren Fänge, Agneta, Sixsmith, J, Tomsone, Signe, HAAK Maria, Haak, Maria, SIXSMITH Judith, Haak, M., Haak, M, Fänge, A. Malmgren, Naumann, D, MALMGREN FÄNGE Anita, Malmgren Fänge, Agneta,, Tomsone, Signe,, Haak, Maria,, Lund University.   +42 more
core   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Health, place and nature : how outdoor environments influence health and well-being : a knowledge base [PDF]

, 2012
This document demonstrates that, for people to be healthy, the environment around us must be health enhancing and provide opportunities to live a healthy life.
Sustainable Development Commission
core   +2 more sources

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

FEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park, Inho Kwon, Yong Hwan Kim, Ji‐Eun Bae, Joon Bum Kim, Seong Hyun Kim, Sungho Maeng, Doo Sin Jo, Dong‐Hyung Cho   +8 more
wiley   +1 more source