Results 81 to 90 of about 9,426,984 (278)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
The Health of the Academic Organization from the Point of View of the Common Living Entity [PDF]
Theoretical and Applied Economics, 2007 The academic organization is a living entity, created by the institution of the community in order to make people to self-govern in a very intelligent way.
Carmen Costea +4 more
doaj +1 more source
The Challenge Op Living With Growth In A Healthy Environment
, 1991 (Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.
openaire +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Journal of PharmacyIntroduction: Home Medication Review (HMR) is crucial for optimising medication use and improving patient’s outcomes. Despite its potential benefits, HMR implementation in rural areas faces challenges.
Norny Syafinaz Ab Rahman +2 more
doaj
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Matrik, 2019 The purposes of the research are to analyzing, evaluating, and measuring the correlation between employee's perception of Germas (healthy life movement) on the behaviour of healthy living in the work environment, according to the recommendations in ...
Regina Nova Indradewi +2 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Jurnal Ilmiah KesehatanMalaria is a tropical disease caused by the bite of the Anopheles mosquito. Malaria is an infectious disease that is of global concern. This disease still often causes extraordinary events.
Rusni +3 more
doaj +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source