Results 111 to 120 of about 87,068,806 (201)

Rewarding behavior change in rural communities: Pathways for a sustained inclusive change for child health. [PDF]

PLOS Glob Public Health
Ali SS, Tabassum F, Delawalla Z, Asim M, Memon MA, Mirani M, Khatoon S, Padhani ZA, Sheikh I, Jamali MK, Mangi KM, Bhutta ZA, Das JK.   +12 more
europepmc   +1 more source

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

The distinctiveness of human aging II: social processes and the regulation of aging. [PDF]

Z Gerontol Geriatr
Dannefer D, Kelley J, Okunade O.
europepmc   +1 more source

Microglial Deubiquitinase OTUD7B Stabilizes STAT3 to Promote Neuroinflammation and Cognitive Decline in Alzheimer's Disease

Advanced Science, EarlyView.
. ABSTRACT Neuroinflammation driven by microglial activation is a defining feature of Alzheimer's disease (AD), yet the molecular mechanisms sustaining this proinflammatory state remain unclear. Here, we identify the deubiquitinase OTUD7B as a critical regulator of microglial activation and AD pathology.
Luyao Li, Hao Tang, Qin Yu, Yuyang Zhang, Binglu Shi, Ying Kong, Leiyu Xu, Jingjing Shao, Chenghong Hu, Lingyu She, Zhe Wang, Haiyi Chen, Aleksandr V. Samorodov, Gang Cao, Xia Zhao, Yi Wang   +15 more
wiley   +1 more source

Addressing substance use and mental illness among Quinault Indian Nation adolescents and young adults: community perspectives on community and cultural connection. [PDF]

Addict Sci Clin Pract
Simon CB, Mackaronis J, Austin EJ, Bentley MJ, Gill J, Kalama E, Charley S, Nelson JJ, Hallgren KA, Williams EC.   +9 more
europepmc   +1 more source

A Clinical Study of Decellularized Tissue Engineering Hyaline Cartilage Graft (dLhCG) for Articular Cartilage Repair

Advanced Science, EarlyView.
ABSTRACT Current clinical approaches for knee cartilage repair are often limited by hypertrophy and fibrosis in the regenerated tissues. A decellularized tissue‐engineered hyaline cartilage graft (dLhCG), composed of a type II collagen‐based extracellular matrix, has been developed to overcome this limitation.
Zhen Zhang, Gong Cheng, Wenyong Fei, Qiuzhen Liang, Liang Zhang, Kegui Liu, Jihang Dai, Bo Cong, Xu Hu, Zhonglian Wu, Jialu Zhang, Jinlan Cui, Hang Yao, Dong‐An Wang, Jingcheng Wang, Tao Sun, Jiang Zheng   +16 more
wiley   +1 more source

The 2026 Oceania Report of the MJA-Lancet Countdown on Health and Climate Change: Children Already Impacted, With a Lifetime of Exposure to Come. [PDF]

Med J Aust
Beggs PJ, Singh T, Bambrick H, Borchers Arriagada N, Bowen K, Capon AG, Colagiuri P, Crandon T, Cross TJ, Dimer L, Green D, Hanigan IC, Heenan M, Ho T, Jay O, Kennard HR, Langridge F, Linnenluecke MK, Lokmic-Tomkins Z, Lovett R, MacGregor C, Malik A, Markey-Towler R, Matthews V, McKay CD, McMichael C, Nice K, Peel J, Seneviratne S, Sievert K, Smallcombe J, Stevenson M, Trueck S, Vardoulakis S, Vyas A, Wilkes B, Williams JTW, Woodward AJ, Zhang Y, Hasan MM, Romanello MB.   +40 more
europepmc   +1 more source

Gm26550 Modulates Learning and Memory by Increasing IGF1 mRNA Expression and Stability in Nrf2−/− Mice

Advanced Science, EarlyView.
The present study shows that Nrf2 directly binds to the Gm26550 promoter, thereby activating Gm26550 transcription and increasing its expression. Mechanistically, Gm26550 promotes IGF1 expression by functionally antagonizing miR‐26a‐5p‐mediated repression and sequestering the RBP KHSRP, thereby enhancing hippocampal neuronal synaptic plasticity and ...
Hongfang Wang, Ziyao Wang, Dongyue Zuo, Zhaowen Su, Bowen Song, Jiamin Gao, Yizhou Zhang, Ruiting Zhao, Linjie Sun, Mengdi Li, Yirui Fan, Dandan Geng, Lei Wang   +12 more
wiley   +1 more source

Indigenous Culture and Health in UDRH Research: An Indigenous-Led Narrative Review. [PDF]

Aust J Rural Health
Watkins M, Kelly C, Green C, Bay S, Minahan G, Sangelaji B, Thompson SC.   +6 more
europepmc   +1 more source

Ultrasound‐Activatable Piezoelectric Hydrogel Reprograms Mitochondrial Epigenetics for Osteoarthritis Therapy via the mTOR/GATD3A Axis

Advanced Science, EarlyView.
An ultrasound‐activatable piezoelectric hydrogel reprograms chondrocyte mitochondrial epigenetics via the mTOR/GATD3A axis, clearing damaged mitochondria and alleviating osteoarthritis progression in both mouse models and human cartilage explants. ABSTRACT The avascular nature of cartilage hinders drug delivery for osteoarthritis (OA) therapy.
Hui Zheng, Pengfei Yan, Peng Liu, Chang Yan, Mengqi Zhao, Zuyong Wang, Chao Ma, Rongkai Zhang, Xi Cui, Swee Hin Teoh   +9 more
wiley   +1 more source