Results 31 to 40 of about 88,519 (219)

The Summit on Creativity and Aging in America [PDF]

, 2016
This report looks at how the federal government can leverage the arts to foster healthy aging and inclusive design for this growing population. This white paper features recommendations from the May 2015 Summit on Creativity and Aging in America, a ...
Ace Everett, Gay Hanna, Janice Blanchard, Judith-Kate Friedman, Judy Rollins, Linda Noelker, Paula Cleggett, Tobi Abramson   +7 more
core  

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Genetic Risk for Alzheimer\u27s Disease Alters the Five-Year Trajectory of Semantic Memory Activation in Cognitively Intact Elders [PDF]

, 2015
Healthy aging is associated with cognitive declines typically accompanied by increased task-related brain activity in comparison to younger counterparts.
Bonner-Jackson, Aaron, Durgerian, Sally, Nielson, Kristy A, Rao, Stephen M., Seidenberg, Michael, Smith, J. Carson, Woodard, John L.   +6 more
core   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Dampier Peninsula\u27s Community Navigators: Empowering Kimberley Families through their Aboriginal-led Woombooriny Amboon Angarriiya Partnership Initiative (WAAPI) [PDF]

, 2019
The Dampier Peninsula is home to a pristine coastal landscape and rugged country with diverse and abundant marine life, flora and fauna. Valuable Aboriginal cultural knowledge, traditions and science are still shared and practiced, while local tourism ...
Augustine, Joshua, Bunning, Jessica, Isaac, Janella, Sampi, Belinda, Smith, Rosana   +4 more
core   +1 more source

Toward a culturally sensitive conceptualization of resilience: participatory research with war-affected communities in northern Uganda [PDF]

, 2015
Resilience research with war-affected populations has long conceptualized resilience as the absence of psychopathology and operationalized it by use of standardized measures.
Ager, Alastair, Broekaert, Eric, Derluyn, Ilse, Schiltz, Julie, Vindevogel, Sofie   +4 more
core   +2 more sources

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

“Listen Carefully:” A Study of Ageist Stereotypes and Undergraduates’ Desire to Work with Elders [PDF]

, 2013
“Listen Carefully:” A Study of Ageist Stereotypes and Undergraduates’ Desire to Work with Elders identifies and assesses how prior experience with elders and ageist stereotypes informs the degree to which undergraduates are inclined (or disinclined) to ...
Ilg, Genevieve
core   +1 more source