Results 141 to 150 of about 6,141,168 (386)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

2012 Annual Report: Achieving Access to Health for All Coloradans [PDF]

open access: yes, 2013
This annual report includes: an 'about us' introduction, a letter from the leadership, details of grantmaking activities in the areas of health data and information, health advocacy and policy, health care services and systems, and health and well-being,

core  

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

open access: yesMolecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad   +12 more
wiley   +1 more source

National Blueprint: Increasing Physical Activity Among Adults Age 50 and Older [PDF]

open access: yes, 2001
Outlines a variety of approaches for organizations, associations, and agencies to plan strategies to help people age 50 and older increase their physical ...

core  

Strength through diversity: how cancers thrive when clones cooperate

open access: yesMolecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken   +3 more
wiley   +1 more source

Community Building and Organizing Initiative Annual Report 2007-2008 [PDF]

open access: yes, 2009
Annual report of NeighborWorks America's Community Building and Organizing ...

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Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

open access: yesMolecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié   +13 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

American Recovery and Reinvestment Act: A Guide to Housing Related Opportunities for Making Connections Communities [PDF]

open access: yes, 2009
Outlines stimulus funding for housing-related programs and coordinated strategies to help low-income communities benefit. Suggests policies to promote, including advancing green and healthy housing and addressing the foreclosure crisis.
Jeffrey Lubell, Megan Richardson
core  

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