Results 251 to 260 of about 818,795 (308)

Healthy volunteer studies in toxicology

Toxicology Letters, 1998
In the future there will be an increasing need for quantitative human risk assessment in order to develop soundly-based risk level regulations. Human volunteer studies can contribute to gain essential data needed for this risk assessment. Volunteer studies are especially relevant to study the biokinetics and metabolism of a compound.
Meulenbelt, J, Mensinga, TT, Kortboyer, JM, Speijers, GJA, de Vries, I   +4 more
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Topical Amitriptyline in Healthy Volunteers

Regional Anesthesia and Pain Medicine, 2003
The antidepressant amitriptyline is used as an adjuvant in the treatment of a variety of chronic pain conditions. This drug interacts with many receptors and ion channels, such as Na+ channels. In a randomized, double-blinded, and placebo-controlled trial, we investigated whether amitriptyline also is capable of providing cutaneous analgesia when ...
Peter, Gerner, Grace, Kao, Venkatesh, Srinivasa, Sanjeet, Narang, Ging Kuo, Wang   +4 more
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Cyclosporine Kinetics in Healthy Volunteers

The Journal of Clinical Pharmacology, 1987
The pharmacokinetics of cyclosporine was studied in five healthy male volunteers following intravenous administration. The subjects received 2.1 mg/kg of cyclosporine as a two‐hour intravenous infusion. Blood samples were collected over the subsequent 48 hours.
R J, Ptachcinski, R, Venkataramanan, G J, Burckart, J A, Gray, D H, Van Thiel, A, Sanghvi, J T, Rosenthal   +6 more
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Capecitabine bioequivalence in healthy volunteers

Int. Journal of Clinical Pharmacology and Therapeutics, 2018
Capecitabine is a prodrug and is selectively activated by tumor cells to its cytotoxic moiety, 5-fluorouracil, by thymidine phosphorylase, which is generally expressed at high levels in tumors. Clinical and pharmacokinetic studies of capecitabine have been performed in patients with cancer.
Mariana, Machado Matos, Renan Arthur, Bosio-Guimarães, Ana Júlia, Schmidt Niederauer, Katia Isabel Fercondini, Pastre, Ronilson A, Moreno, Simone Grigoletto, Schramm, Paulo Alexandre Rebelo, Galvinas, Gustavo D, Mendes, Gilberto, De Nucci   +8 more
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Urorectodynamic evaluation of healthy volunteers

Urology, 1982
Twelve female and 8 male healthy volunteers underwent urorectodynamic evaluation. Mean bladder capacity was 594 ml. and mean maximal vesical pressure 12.5 cm. water (H2O). Maximal bladder pressure correlated significantly with maximal mural tension (r = 0.96) but did not correlate well with bladder capacity (r = 0.20).
M, Abdel-Rahman, A, Coulombe, G, Devroede, A, Toppercer, C, Duguay, L, Lapointe, M, Elhilali   +6 more
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Amlodipine Pharmacokinetics in Healthy Volunteers

The Journal of Clinical Pharmacology, 1988
In the present study we investigated the pharmacokinetics and comparative bioavailability of three oral doses of amlodipine in 12 healthy male volunteers. A randomized, open‐label, three period crossover study design was employed. Each subject received, on three separate occasions a single oral dose of 2.5, 5 and 10 mg amlodipine.
D M, Williams, L X, Cubeddu
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Phenytoin Binding in Healthy Volunteers

Therapeutic Drug Monitoring, 1987
The pharmacologic effect of phenytoin is directly related to the unbound concentration in the serum, which previously has been reported in the literature to be approximately 10%. The results of 13 out of 14 20-35 year-old healthy male volunteers studied indicate that less than 10% unbound phenytoin is present in the majority of subjects taking two ...
M J, Berg, B E, Ebert, R W, Fincham, D D, Schottelius   +3 more
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Antithrombin III: Biodistribution in Healthy Volunteers

Thrombosis and Haemostasis, 1987
SummaryFive healthy volunteers were injected intravenously with 73-90 uCi purified human 131I-Antithrombin III (AT III), specific biological activity 5.6 U/mg. The tracer data were analysed using a three compartment model. The plasma radioactivity half life was 66.2 ± 1.2 (sem) h, the fractional catabolic rate constant of the plasma pool was 0.025 ± 0 ...
Knot, E. A., de Jong, E., ten Cate, J. W., Gie, L. K., van Royen, E. A.   +4 more
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Electrical impedance myography in healthy volunteers

Muscle & Nerve, 2023
AbstractIntroduction/AimsElectrical impedance myography (EIM) is a noninvasive technique being used in clinical studies to characterize muscle by phase, reactance, and resistance after application of a low‐intensity current. The aim of this study was to obtain 50‐kHz EIM data from healthy volunteers (HVs) for use in future clinical and research studies,
Michelle B. Offit, Hadi Mohammad Khanli, Tianxia Wu, Tanya J. Lehky   +3 more
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Healthy Volunteers

2020
Abstract This chapter describes the involvement of healthy volunteers in biomedical research. Healthy individuals are valuable to research because they can offer data about biological processes or investigational products that are not distorted by illness or disease.
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