Results 271 to 280 of about 818,795 (308)

Vitamin K status in healthy volunteers

Food Funct., 2014
Vitamin K's recommended dietary allowance (RDA) is based on the hepatic requirement for clotting factor synthesis, but substantial concentrations of undercarboxylated extra-hepatic Gla-proteins are found in the circulation of non-supplemented individuals. This suggests that vitamin K intake above the RDA is required for an optimal extra-hepatic vitamin
Theuwissen, E., Magdeleyns, E. J., Braam, L. A. J. L. M., Teunissen, K. J., Knapen, M. H., Binnekamp, I. A. G., van Summeren, M. J. H., Vermeer, C.   +7 more
openaire   +2 more sources

Healthy Volunteer Effect in Industrial Workers

Journal of Clinical Epidemiology, 1999
Volunteers for epidemiological research, have lower mortality rates than non-volunteers, thereby producing a bias referred to as the "healthy volunteer effect" (HVE). Occupationally active persons have been similarly shown to have a reduced mortality relatively to the general population (the "healthy worker effect").
P, Froom, S, Melamed, E, Kristal-Boneh, J, Benbassat, J, Ribak   +4 more
openaire   +2 more sources

Pharmacokinetics of oxypolygelatine in healthy volunteers

European Journal of Clinical Pharmacology, 1999
The pharmacokinetics of the plasma substitute oxypolygelatine (OPG) were studied in 12 healthy volunteers after single-dose administration of 27 ml x kg(-1) body weight, with a maximum of 2000 ml. OPG was determined in plasma and urine over 48 h after the infusion. Peak plasma OPG concentrations at the end of the infusion were determined to 4.600 (623)
P A, Thürmann, R, Lissner, W G, Struff, S, Harder   +3 more
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Pharmacokinetics of Nilvadipine in Healthy Volunteers

The Journal of Clinical Pharmacology, 1987
The pharmacokinetics of nilvadipine, a new antihypertensive and antianginal drug, were examined in healthy male volunteers. In a Latin square, three‐way crossover design with a one‐day run‐in period, six subjects in three groups of two each were given single 2‐, 4‐, or 6‐mg oral doses of nilvadipine after overnight fasting.
M, Terakawa, Y, Tokuma, A, Shishido, H, Noguchi   +3 more
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Endoscopy-Based Research in Healthy Volunteers

Digestive Diseases, 2002
The role of healthy volunteers (HV) in research covers a wide spectrum. In gastrointestinal research HV are often considered a control population. Endoscopy-based investigations are rare in terms of all studies performed in this field. The term ‘healthy’ must be questioned in some cases, as <i>Helicobacter pylori-</i>positive individuals ...
Gerhard, Treiber, Peter, Malfertheiner
openaire   +2 more sources

Disposition of desloratadine in healthy volunteers

Xenobiotica, 2007
The absorption, metabolism and excretion of desloratadine (DL, Clarinex) were characterized in six healthy male volunteers. Subjects received a single oral 10-mg dose of [(14)C]DL ( approximately 104 microCi). Blood, urine and feces were collected over 240 h.
R, Ramanathan, L, Reyderman, A-D, Su, N, Alvarez, S K, Chowdhury, K B, Alton, M A, Wirth, R P, Clement, P, Statkevich, J E, Patrick   +9 more
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Nd and P300 in Healthy Volunteers

Environmental Research, 1993
We attempted to standardize values of the attention-related negative potential (Nd) and the P300 in 100 healthy volunteers (50 females, 50 males) who were given the task of making dichotic syllable discriminations requiring key-press responses. Ages ranged between 18 and 59 years.
S, Niwa, S, Hayashida
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Global Efforts to Protect Healthy Volunteers

Hastings Center Report, 2023
AbstractClinical trials on healthy volunteers generate unique ethical challenges both because participants accept potential physical risks without the possibility of direct medical benefit and because participants’ financial motivations to enroll in trials could lead to their exploitation.
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Pharmacokinetics of imipenem in healthy volunteers

Journal of Antimicrobial Chemotherapy, 1983
The pharmacokinetics of imipenem were evaluated in four studies involving 49 healthy men, several of whom participated in more than one study. Within a dose-range of 150 to 1000 mg, imipenem was found to give high plasma concentrations, proportional to the size of the dose.
S R, Norrby, B, Björnegård, F, Ferber, K H, Jones   +3 more
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Bioavailability of dihydroergosine in healthy volunteers

European Journal of Drug Metabolism and Pharmacokinetics, 1987
Eight healthy volunteers received an oral dose of 10 mg and an intravenous dose of 0.75 mg of dihydroergosine. Plasma concentrations were measured by HPLC method, and some pharmacokinetic parameters were calculated. The biologic half-life in the elimination phase was 8.35 +/- 1.87 h after oral administration and 8.84 +/- 3.64 h after intravenous ...
P, Cvelbar, J, Culig, Z, Kopitar, A, Lenardic, J U, Smerkolj, M, Zorz   +5 more
openaire   +2 more sources