Results 31 to 40 of about 818,795 (308)

Role of N-methyl-D-aspartate receptors in action-based predictive coding deficits in schizophrenia [PDF]

, 2017
Published in final edited form as:Biol Psychiatry. 2017 March 15; 81(6): 514–524. doi:10.1016/j.biopsych.2016.06.019.BACKGROUND: Recent theoretical models of schizophrenia posit that dysfunction of the neural mechanisms subserving predictive coding ...
Ford, Judith M., Gunduz-Bruce, Handan, Jaeger, Judith, Kort, Naomi S., Krystal, John H., Mathalon, Daniel H., Reinhart, Robert M.G., Roach, Brian J.   +7 more
core   +1 more source

Nocturnal Changes in Knee Cartilage Thickness in Young Healthy Adults [PDF]

, 2012
Magnetic resonance imaging (MRI) allows one to analyze cartilage physiology in vivo. Cartilage deforms during loading, but little is known about its recovery after deformation.
Eckstein, F., Hudelmaier, M., Sitoci, K. H.   +2 more
core   +1 more source

Kinesiophobia, physical activity levels and barriers in breast cancer patients, survivors, and healthy controls: a case-control analysis

Journal of the Pakistan Medical Association
Objective: To investigate kinesiophobia, physical activity levels and barriers to physical activity in women with breast cancer and breast cancer survivors. Method: The case-control study was conducted at the Breast Clinic of Acibadem Maslak Hospital,
Nuray Alaca, Kubra Turker Karayazi, Dilek Cagri Arslan, Meryem Bektas Karakus, Cihan Uras   +4 more
doaj   +1 more source

Sample size recommendation for a bioequivalent study

Statistica, 2017
There are clear guidelines and suggestions on the sample size and power calculation from health authorities (HA) for Bio equivalence (BE) studies in Healthy volunteers (HV). The suggested power is at least 80\% and type 1 error is 5\%.
Chandrasekhar Bhupathi, Venakata HaraGopal Vajjha   +1 more
doaj   +1 more source

Pharmacokinetics of intranasal amiloride in healthy volunteers

Clinical and Translational Science, 2023
Anxiety and panic disorders are the most common mental illnesses in the United States and lack effective treatment options. Acid‐sending ion channels (ASICs) in the brain were shown to be associated with fear conditioning and anxiety responses and ...
Venkata K. Yellepeddi, Marco Battaglia, Simon J. C. Davies, Jeremiah Alt, Shaelene Ashby, Paige Shipman, David J. Anderson, Joseph E. Rower, Christopher Reilly, Michael Voight, Sabiha Rahman Mim   +10 more
doaj   +1 more source

Endostatin concentration in plasma of healthy human volunteers [PDF]

, 2017
Background: Angiogenesis is involved in many cardiovascular and cancerous diseases, including atherosclerosis and is controlled by a fine balance between angiogenic and angiostatic mediators.
Baxendale, Ronald Hugh, Fatima, Sadia, Habib, Syed Hamid, Khan, Muhammad Jaffar, Malik, Muhammad Omar, Shah, Inayat   +5 more
core  

Changes in urine composition after trauma facilitate bacterial growth. [PDF]

, 2012
International audienceUNLABELLED: ABSTRACT: BACKGROUND: Critically ill patients including trauma patients are at high risk of urinary tract infection (UTI). The composition of urine in trauma patients may be modified due to inflammation, systemic stress,
Aubron, Cecile, Borderie, Didier, Bouvet, Odile, Denamur, Erick, Duranteau, Jacques, Huet, Olivier, Leblanc, Pierre-Etienne, Pussard, Eric, Ricome, Sylvie, Vicaut, Eric   +9 more
core   +3 more sources

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source