Results 81 to 90 of about 322,854 (335)

NOX2 Contributes to High‐Frequency Outer Hair Cell Vulnerability in the Cochlea

Advanced Science, EarlyView.
This study first identifies NOX2 as a differentially expressed gene related to oxidative damage in the apical and basal turns through single‐cell RNA sequencing. NOX2 gene knockout mitigates OHCs damage caused by neomycin and noise and enhances Nrf2 expression and nuclear translocation.
Meihao Qi, Zejun Gao, Yang Qiu, Renfeng Wang, Keyong Tian, Bo Yue, Xinyu Zhang, Peng Zhang, Ziqi Wu, Qingwen Zhu, Zhenzhen Liu, Zhuoyao Ma, Xueying Zhou, Yu Han, Jun Chen, Jianhua Qiu, DingJun Zha   +16 more
wiley   +1 more source

Socialization Problems among Hearing-Impaired Children at Special Primary School Establishment [PDF]

, 2011
Problems associated with socialization of children who are hearing impaired in both special primary education institutions and the family are analyzed in this article.
Brokane, Larisa, Zaiceva, Inamora
core   +1 more source

Single Administration of AAV‐mAtp6v1b2 Gene Therapy Rescues Hearing and Vestibular Disorders Caused by Atp6v1b2‐Induced Lysosomal Dysfunction in Hair Cells

Advanced Science, EarlyView.
Wei et al. establish a hair cell‐specific conditional knockout mouse model (Atp6v1b2fl/fl;Atoh1Cre/+), and demonstrate the importance of Atp6v1b2 for hair cell through maintaining the survival of lysosomes. A single administration of AAV‐ie‐Eh3‐mAtp6v1b2 through scala media at P0‐P2 realizes function compensation and restores hearing and balance ...
Gege Wei, Shiwei Qiu, Xue Gao, Lu Zheng, Yijin Chen, Ying Ma, Haifeng Feng, Jinyuan Yang, Guojie Dong, Huiyi Nie, Weihao Zhao, Xiaoge Li, Guangqin Wang, Wei Xiong, Pu Dai, Yongyi Yuan   +15 more
wiley   +1 more source

A BRIDGE BETWEEN WORLDS: COMMUNICATION BETWEEN PARENTS AND A DEAF CHILD [PDF]

Multidisciplinarni Pristupi u Edukaciji i Rehabilitaciji
With the birth of a child, parents are also born. Parents and children develop, grow, learn and make mistakes together. There is no manual to indicate whether parents are making mistakes in raising another being, nor is there a reward when they do ...
Edin Mujkanović, Elvira Mujkanović
doaj   +1 more source

GDC: Integration of Multi‐Omic and Phenotypic Resources to Unravel the Genetic Pathogenesis of Hearing Loss

Advanced Science, EarlyView.
Overview of the Genetic Deafness Commons (GDC), integrating data from the Chinese Deafness Genetics Consortium (CDGC) and 51 public databases. The GDC provides tools for variant search, functional predictions, and gene‐disease visualization, offering insights into 201 hearing loss genes and facilitating novel gene discovery and clinical applications ...
Hui Cheng, Xuegang Wang, Mingjun Zhong, Jia Geng, Wenjian Li, Kanglu Pei, Jing Wang, Lanchen Wang, Yu Lu, Jing Cheng, Fengxiao Bu, Huijun Yuan   +11 more
wiley   +1 more source

Consequences and Mechanisms of Noise‐Induced Cochlear Synaptopathy and Hidden Hearing Loss, With Focuses on Signal Perception in Noise and Temporal Processing

Advanced Science, EarlyView.
Noise‐induced synaptopathy (NIS) is largely reversible due to self‐repair. NIS and noise‐induced hidden hearing loss are two concepts with similarities and differences. The major hearing deficits in NIHHL are temporal processing disorders. The translation of animal data in NIS studies to humans is hindered by many factors.
Hui Wang, Steven J Aiken, Jian Wang
wiley   +1 more source

Performance, fatigue and stress in open-plan offices: The effects of noise and restoration on hearing impaired and normal hearing individuals

Noise and Health, 2012
Hearing impaired and normal hearing individuals were compared in two within-participant office noise conditions (high noise: 60 L Aeq and low noise: 30 L Aeq ).
Helena Jahncke, Niklas Halin
doaj   +1 more source

Exploring person-environment fit towards enhancing hearing-impaired students academic achievement in tertiary education [PDF]

, 2016
Studies involving hearing students at the tertiary level have documented significant predictors of academic achievement relating to various personal and environmental factors.
Asimiran, Soaib, Azizan, Che’ Rozaniza, Chong Abdullah, Maria, Roslan, Samsilah   +3 more
core  

Status quo of inclusive access to higher education : a focus on deaf and hearing-impaired individuals in german-speaking Switzerland [PDF]

, 2018
As numbers of graduates with impairments are actually decreasing, higher education access and study conditions are in need of improvement for students with sensory impairments in Switzerland.
Bouillon, Pierrette, Hohenstein, Christiane, Näf, Manuela, Rodríguez Vázquez, Silvia, Strasly, Irene, Zavgorodnia, Larysa   +5 more
core   +1 more source

Long‐Lasting Auditory and Vestibular Recovery Following Gene Replacement Therapy in a Novel Usher Syndrome Type 1c Mouse Model

Advanced Science, EarlyView.
This study shows that gene replacement therapy using the AAV2/Anc80L65 virus can successfully restore hearing and balance in Ush1c knockout mice. The treatment leads to lasting improvements in both auditory and vestibular functions, highlighting its potential as a therapeutic approach for genetic hearing loss and vestibular disorders in humans ...
Weinan Du, Jun Huang, Aizhen Zhang, Fangfang Zhao, Tianwen Chen, Quinn M. McDermott, Tony Zheng, Haibo Wang, Rongli Zhang, Xiaolin Zhang, Jerome Allison, Hong Zhu, Wu Zhou, Qing Yin Zheng   +13 more
wiley   +1 more source