Results 61 to 70 of about 113,937 (235)

XIAP Stabilizes DDRGK1 to Promote ER‐Phagy and Protects Against Noise‐Induced Hearing Loss

Advanced Science, EarlyView.
Mechanism of GAS‐mediated protection against noise‐induced hearing loss (NIHL). Noise exposure activates the ATF4/eIF2α axis, downregulating XIAP and promoting DDRGK1 degradation, thereby inhibiting ER‐phagy and leading to hair cell (HC) death. GAS treatment rescues XIAP and DDRGK1 expression, reactivating ER‐phagy to mitigate HC loss, synaptic damage,
Lin Yan, Yuhua Zhang, Jiawei Du, Yongjun Zhu, Wei Cao, Yongjie Wei, Han Wu, Shiyu Qiu, Shiyi Pan, Lian Chen, Pingping Liang, Renjie Chai, Jianming Yang, Qiaojun Fang   +13 more
wiley   +1 more source

A Wearable Brain–Computer Interface for Mitigating Car Sickness via Attention Shifting

Advanced Science, EarlyView.
Car sickness poses a major challenge in vehicular travel, yet effective nonpharmacological solutions are scarce. We developed a wearable, closed‐loop mindfulness BCI that uses real‐time EEG‐based neurofeedback to shift attention away from motion‐induced discomfort. Validated in real‐car experiments involving >100$>100$ susceptible individuals, over 83%
Jiawei Zhu, Xiaoyu Bao, Qiyun Huang, Tao Wang, Li Huang, Haiyun Huang, Junbiao Zhu, Jun Qu, Kendi Li, Di Chen, Ya Jiang, Kailin Xu, Zijian Wang, Wei Wu, Yuanqing Li   +14 more
wiley   +1 more source

WORKPLACE CHALLENGES AND INCLUSION OF GRADUATE EMPLOYEES WITH HEARING IMPAIRMENT IN OYO STATE, NIGERIA

Turkish International Journal of Special Education and Guidance & Counselling
Despite increasing efforts to promote workplace inclusivity, employees with hearing impairment continue to face barriers that limit their participation and professional growth.
Faisat Omolara BELLO, Anuoluwapo Elizabeth ADEDUYIGBE   +1 more
doaj  

Mitochondrial tRNASer(UCN) mutations associated non-syndromic sensorineural hearing loss in Chinese families

Heliyon
Mitochondrial transfer RNA mutation is one of the most important causes of hereditary hearing loss in humans. Mitochondrial transfer RNASer (UCN) gene is another hot spot for mutations associated with non-syndromic hearing loss, besides the 12S ribosomal
Dejun Zhang, Jie Wu, Yongyi Yuan, Xiaohong Li, Xue Gao, Dongyang Kang, Xin Zhang, Sha-sha Huang, Pu Dai   +8 more
doaj   +1 more source

Gut–Metabolome–Proteome Interactions in Age‐Related Hearing Loss: Insights from Fecal Microbiota Transplantation and Multi‐Omics Analyses

Advanced Science, EarlyView.
Germ‐free (GF) mice receiving fecal microbiota transplantation (FMT) reveal microbiota‐dependent effects on auditory aging. Integrated metagenomic, metabolomic and proteomic profiling maps gut–inner ear network and highlights 5‐hydroxytryptophan (5‐HTP) as a microbiota‐linked metabolic hub in age‐related hearing loss (ARHL).
Ting Yang, Ziwen Gao, Hui Huang, Chanyuan Zhang, Yiquan Tang, Qianhui Qu, Huabin Li, Jing Ke, Zhiji Chen, Menglong Feng, Hu Zhou, Yilai Shu, Wei Yuan   +12 more
wiley   +1 more source

Deciphering and Targeting the Schwannoma‐Neuron‐Macrophage Crosstalk for the Treatment of Schwannomatosis and Associated Pain

Advanced Science, EarlyView.
We established patient‐derived SWN cell lines and orthotopic PDX models that recapitulate patient pain phenotypes, alongside a novel intravital DRG imaging platform to track macrophage infiltration and neuronal pain responses. Using these models, we define HMGB1–CCL2–IL‐6 signaling crosstalk driving pain and identify EGF signaling as a key regulator of
Zhenzhen Yin, Limeng Wu, Yanling Zhang, Yao Sun, Grace Y. Lee, Simeng Lu, Xing Gao, John W. Chen, Sonu Subudhi, William Ho, Chao Zhu, Jun Ren, Gino B. Ferraro, Alona Muzikansky, Anat Stemmer‐Rachamimov, Jianren Mao, Scott R. Plotkin, Lei Xu   +17 more
wiley   +1 more source

The effect of right versus left long-term single-sided deafness on sound source localization

Journal of Otology
Purpose: To analyze the effect of right versus left long-term single-sided deafness (SSD) on sound source localization (SSL), discuss the necessity of intervention and treatment for SSD patients, and analyze the therapeutic effect of long-term unilateral
Qingqing Xia, Shuoshuo Kang, Qian Wang, Mengdi Hong, Aiting Chen, Wei Chen, Fei Ji, Jianan Li, Shiming Yang   +8 more
doaj   +1 more source

Relationships between dipstick proteinuria and risk of hearing impairment among Japanese workers: a prospective cohort study

BMJ Open, 2019
Objectives Hearing impairment is among the most significant health problems, and the number of adults with hearing impairment is increasing worldwide. Therefore, the prevention of hearing impairment is important.
Mitsumasa Umesawa, Toshimi Sairenchi, Yasuo Haruyama, Gen Kobashi, Mikako Hara   +4 more
doaj   +1 more source

Ultrasound Modulation of Visual Circuits in Mice Independent of Auditory Confound

Advanced Science, EarlyView.
In this study, Qiu et al. found that low‐intensity ultrasound can directly activate sparse ultrasound‐sensitive neurons (UNs) in the primary visual cortex (V1) of deafened mice. The proportion of these sparse UNs is pressure‐dependent. Furthermore, ultrasound modulates visual circuitry with distinct excitatory and inhibitory effects.
Jiaru He, Jiejun Zhu, Xinxin Wang, Zihao Chen, Jin Yang, Zhen Yuan, Hongzhi Xu, Lei Sun, Zhihai Qiu   +8 more
wiley   +1 more source

Functional characterization of MFSD3 in auditory system and zebrafish embryogenesis

Frontiers in Genetics
The solute carriers (SLCs) are important membrane-bound transporters that regulate cellular nutrition, metabolism, homeostasis and survival. Emerging evidence highlights the critical involvement of SLCs in auditory physiology.
Ying Ma, Ying Ma, Ying Ma, Ying Ma, Ying Ma, Shi-Wei Qiu, Shi-Wei Qiu, Wei-Qian Wang, Hai-Feng Feng, Hai-Feng Feng, Hai-Feng Feng, Hai-Feng Feng, Hai-Feng Feng, Lu Zheng, Lu Zheng, Lu Zheng, Lu Zheng, Lu Zheng, Ge-Ge Wei, Ge-Ge Wei, Ge-Ge Wei, Ge-Ge Wei, Ge-Ge Wei, Hui-Yi Nie, Hui-Yi Nie, Hui-Yi Nie, Hui-Yi Nie, Hui-Yi Nie, Jin-Yuan Yang, Jin-Yuan Yang, Jin-Yuan Yang, Jin-Yuan Yang, Jin-Yuan Yang, Yi-Jin Chen, Yi-Jin Chen, Yi-Jin Chen, Yi-Jin Chen, Yi-Jin Chen, Pu Dai, Pu Dai, Pu Dai, Pu Dai, Pu Dai, Xue Gao, Yong-Yi Yuan, Yong-Yi Yuan, Yong-Yi Yuan, Yong-Yi Yuan, Yong-Yi Yuan   +48 more
doaj   +1 more source