Results 81 to 90 of about 139,396 (311)

Antioxidants and Vasodilators for the Treatment of Noise-Induced Hearing Loss: Are They Really Effective?

Frontiers in Cellular Neuroscience, 2020
We live in a world continuously immersed in noise, an environmental, recreational, and occupational factor present in almost every daily human activity. Exposure to high-level noise could affect the auditory function of individuals at any age, resulting ...
J. Alvarado, V. Fuentes-Santamaría, J. Juiz   +2 more
semanticscholar   +1 more source

SKOOTS: Skeleton‐Oriented Object Segmentation for Mitochondria in High‐Resolution Cochlear EM Datasets

Advanced Science, EarlyView.
Skeleton‐oriented object segmentation (SKOOTS) introduces a new strategy for 3D mitochondrial instance segmentation by predicting explicit skeletons rather than relying on boundary cues. This approach enables robust analysis of densely packed organelles in large FIB‐SEM datasets.
Christopher J. Buswinka, Richard T. Osgood, Hidetomi Nitta, Artur A. Indzhykulian   +3 more
wiley   +1 more source

NADPH Oxidase 3 Deficiency Protects From Noise-Induced Sensorineural Hearing Loss

Frontiers in Cell and Developmental Biology, 2022
The reactive oxygen species (ROS)-generating NADPH oxidase NOX3 isoform is highly and specifically expressed in the inner ear. NOX3 is needed for normal vestibular development but NOX-derived ROS have also been implicated in the pathophysiology of ...
Francis Rousset, German Nacher-Soler, Vivianne Beatrix Christina Kokje, Vivianne Beatrix Christina Kokje, Stéphanie Sgroi, Marta Coelho, Karl-Heinz Krause, Pascal Senn, Pascal Senn   +8 more
doaj   +1 more source

Noise-induced and age-related hearing loss: new perspectives and potential therapies

F1000Research, 2017
The classic view of sensorineural hearing loss has been that the primary damage targets are hair cells and that auditory nerve loss is typically secondary to hair cell degeneration. Recent work has challenged that view.
R. J. Salvi
semanticscholar   +1 more source

Restoring Iron Homeostasis via Smoothened Inhibition: A Novel Strategy Against Hearing Loss

Advanced Science, EarlyView.
 . ABSTRACT Sensorineural hearing loss (SNHL) induced by noise or aminoglycoside antibiotics is a significant public health concern without any FDA‐approved pharmaceutical therapies. Dysregulation of iron homeostasis and its subsequently induced ferroptosis has increasingly been identified as a key mechanism underlying cochlear hair cell (HC) damage ...
Huanyu Mao, Xiang Li, Yaqi Liao, Liman Liu, Xian Gao, Hailiang Lin, Wenli Ni, Huawei Li, Yan Chen, Wenyan Li   +9 more
wiley   +1 more source

Auditory fatigue model applications to predict noise induced hearing loss in human and chinchilla [PDF]

, 2016
Noise induced hearing loss (NIHL) remains a severe health problem worldwide. Current noise metrics and models have assessment limitations on gradually developing NIHL (GDNIHL). In this study, we apply a complex velocity level (CVL) auditory fatigue model
Campbell, Kathleen, Fox, Daniel, Qin, Jun, Sun, Pengfei   +3 more
core   +2 more sources

Cancer therapy‐induced ototoxicity: Current challenges and emerging management strategies

Animal Models and Experimental Medicine, EarlyView.
This review comprehensively examines the key risk factors for cancer therapy‐induced ototoxicity, including cumulative drug dose, genetic susceptibility, and combined treatment regimens. It highlights current challenges in ototoxicity monitoring, such as insufficient timeliness and limited clinical adoption, and advocates for standardized auditory ...
Yuqi Huang, Baoying Xu, Xinru Chen, Yu Chen, Dehong Yu   +4 more
wiley   +1 more source

Time course of cell death due to acoustic overstimulation in the mouse medial geniculate body and primary auditory cortex

Noise and Health, 2017
It has previously been shown that acoustic overstimulation induces cell death and extensive cell loss in key structures of the central auditory pathway. A correlation between noise-induced apoptosis and cell loss was hypothesized for the cochlear nucleus
Felix Frohlich, Dietmar Basta, Ira Strübing, Arne Ernst, Moritz Gröschel   +4 more
doaj   +1 more source

Nondeterministic nature of sensorineural outcomes following noise trauma

Biology Open, 2021
Over 1.1 billion individuals are at risk for noise induced hearing loss yet there is no accepted therapy. A long history of research has demonstrated that excessive noise exposure will kill outer hair cells (OHCs).
O'neil W. Guthrie, Ishan S. Bhatt
doaj   +1 more source

Immersive reality capabilities of relieving hiraeth

Journal of the Association for Information Science and Technology, EarlyView.
Abstract Understanding how immersive experiences foster a sense of presence sufficient to rival real‐world experiences remains an open research area. Prior work has largely examined episodic memory recall in simulated environments, but less is known about how immersive technologies can reconnect individuals with personal memories.
Erica Mi, Fred Fonseca
wiley   +1 more source