Results 131 to 140 of about 4,375,853 (312)

Brain Network Dynamics of Local and Global Predictive Processing in Aging

Advanced Science, EarlyView.
Separation of concurrent whole‐brain networks in source‐reconstructed magnetoencephalography (MEG) data suggests that healthy aging reorganizes, rather than uniformly attenuates, neural responses elicited from hierarchical auditory violations. Enhanced early sensory deviance processing alongside reduced higher‐order cognitive responses suggests a large‐
Mathias Houe Andersen, Gemma Fernández‐Rubio, David R. Quiroga‐Martinez, Mattia Rosso, Mathias Klarlund, Kit Melissa Larsen, Hartwig Roman Siebner, Morten L. Kringelbach, Peter Vuust, Leonardo Bonetti   +9 more
wiley   +1 more source

Retrospective Grid Cells in the Medial Entorhinal Cortex Encode Past Paths During Spatial Navigation

Advanced Science, EarlyView.
Retrospective grid cells are identified in the medial entorhinal cortex, with spatial firing patterns that become most grid‐like when activity is projected onto recently traversed locations. Their coding loses spatial precision in darkness and is disrupted during assisted movement, indicating that entorhinal representations incorporate recent path ...
Ruojin Liu, Xin Yuan, Zilong He, Hong Jin, Jiayi Tian, Cong Chen, Yuanjing Liu, Xiang Zhang, Shidan Wen, Emilio Kropff, Chenglin Miao   +10 more
wiley   +1 more source

Role of Hearing Loss in Otolaryngology Surgical Outcomes

Ear, Nose & Throat Journal
Objective The role of hearing loss (HL) in surgical outcomes is not well studied and could greatly impact the lives of patients in the post-operative setting. Study Design This is a retrospective cohort study of adults who underwent ...
Quentin C. Durfee, Hänel W. Eberly, David Goldrich, Mark Whitaker, Varun S. Patel   +4 more
openaire   +2 more sources

A Molecularly Defined Midbrain Circuit Mechanism for Sound‐Driven Defensive Behavior and Anxiety

Advanced Science, EarlyView.
Schematic diagram showing the Cbln2+ ICx–dPAG circuit for sound‐driven defensive and anxiety‐like behaviors. ABSTRACT The innate defense behaviors in response to threatening sounds play a fundamental role in survival. However, the neural circuits that detect threat‐relevant auditory cues and transform them into defensive behaviors remain poorly defined.
Jie Cao, Xingxing Lai, Lifang Huo, Zhouyuan Zheng, Qian Zhang, Zhimin Ye, Panpan Wan, Chao Ma, Congping Shang   +8 more
wiley   +1 more source

Newborn hearing screening: outcomes and management of infants

Revista da Associação Médica Brasileira
SUMMARY OBJECTIVE: The aim of this study was to evaluate the prevalence and characteristics of hearing loss among infants referred after newborn hearing screening in a tertiary referral center in Türkiye and to examine its association with demographic and clinical risk factors.
Hatice Kübra Bozkurt, Fatma Ceyda Akın Öçal, Ercan Karababa, Ayşe Nur Balaban, Rumeysa Nur Akbaş, Öykü Özbaş Kes, Emine Aydın   +6 more
openaire   +3 more sources

Galactokinase 1 Positively Regulates Mitochondrial Respiration by Phosphorylating TIMM13 as a Protein Kinase

Advanced Science, EarlyView.
GALK1 acts as a protein kinase beyond the phosphorylation of galactose. GALK1 phosphorylates TIMM13 at Y73 in the cytoplasm. This phosphorylation prevents premature oxidative folding of TIMM13 and ensures its entrance into the intermembrane space of mitochondrion, positively regulating mitochondrial respiration.
Chang Woo Ko, Dongyoon Shin, Junho Park, June Huh, Youngsoo Kim, Jong‐Wan Park   +5 more
wiley   +1 more source

Hearing Outcomes Reporting in Lateral Skull Base Surgery

, 2018
Hearing outcomes reporting has evolved significantly and new standards for reporting now enable a more precise and comprehensive representation of hearing outcomes.
Gurgel, Richard K., Bowers, Christian A., Casazza, Geoffrey, Christian Bowers, Geoffrey Casazza, Richard Gurgel   +5 more
core   +1 more source

ENHANCE: a comparative prospective longitudinal study of cognitive outcomes after 3 years of hearing aid use in older adults

Frontiers in Aging Neuroscience
BackgroundWith an aging population, the prevalence of hearing loss and dementia are increasing rapidly. Hearing loss is currently considered the largest potentially modifiable risk factor for dementia.
Julia Z. Sarant, Peter A. Busby, Adrian J. Schembri, Christopher Fowler, David C. Harris   +4 more
doaj   +1 more source

WFS1 Deficiency Impairs PIAS4‐Associated SUMOylation and Increases Ubiquitin‐Mediated Spermatogenesis‐Related Protein Degradation Leading to Testicular Male Infertility

Advanced Science, EarlyView.
The findings establish a critical role for WFS1 in human male fertility. Mechanistically, WFS1 interacts with PIAS4 to promote the SUMOylation of key spermatogenesis‐associated proteins, which in turn competitively inhibits their K48‐linked ubiquitin‐mediated degradation during spermatogenesis.
Yunchuan Tian, Guicheng Zhao, Xiang Wang, Xinyao Tang, Gan Shen, Tiechao Ruan, Chuan Jiang, Shikun Zhao, Jincheng Zhang, Xinyue Cui, Liangchai Zhuo, Jun Ma, Yihong Yang, Tingting Lin, Ying Shen   +14 more
wiley   +1 more source

Comparisons of Functional, Physical, and Mental Health Outcomes Among Young and Old Stroke Survivors

Geriatrics
Objective: The objective of this study was to examine how functional, mental, and physical health outcomes differ between younger (
Molly M. Jacobs, Charles Ellis
doaj   +1 more source