Results 111 to 120 of about 1,913,146 (301)

Transient Sleep Deprivation Induces Persistent Auditory Neuropathy via ROS‐Initiated Neuroinflammation and BK Channel Suppression

Advanced Science, EarlyView.
Sleep disturbance severity closely tracks hearing loss in a clinical cohort, yet the mechanistic link remains unclear. Acute sleep deprivation is shown to trigger transient cochlear oxidative stress that switches into a self‐sustaining neuroinflammatory state, suppressing BK channels and causing irreversible synaptopathy.
Dan Chen, Ying Ma, Lixuan Huang, Xin Chen, Fanliang Kong, Zhenzhou Qian, Mingyue Guan, Xinlin Wang, Yanyan Yang, Shasha Zhang, Peng Li, Renjie Chai   +11 more
wiley   +1 more source

Brain Network Dynamics of Local and Global Predictive Processing in Aging

Advanced Science, EarlyView.
Separation of concurrent whole‐brain networks in source‐reconstructed magnetoencephalography (MEG) data suggests that healthy aging reorganizes, rather than uniformly attenuates, neural responses elicited from hierarchical auditory violations. Enhanced early sensory deviance processing alongside reduced higher‐order cognitive responses suggests a large‐
Mathias Houe Andersen, Gemma Fernández‐Rubio, David R. Quiroga‐Martinez, Mattia Rosso, Mathias Klarlund, Kit Melissa Larsen, Hartwig Roman Siebner, Morten L. Kringelbach, Peter Vuust, Leonardo Bonetti   +9 more
wiley   +1 more source

Retrospective Grid Cells in the Medial Entorhinal Cortex Encode Past Paths During Spatial Navigation

Advanced Science, EarlyView.
Retrospective grid cells are identified in the medial entorhinal cortex, with spatial firing patterns that become most grid‐like when activity is projected onto recently traversed locations. Their coding loses spatial precision in darkness and is disrupted during assisted movement, indicating that entorhinal representations incorporate recent path ...
Ruojin Liu, Xin Yuan, Zilong He, Hong Jin, Jiayi Tian, Cong Chen, Yuanjing Liu, Xiang Zhang, Shidan Wen, Emilio Kropff, Chenglin Miao   +10 more
wiley   +1 more source

A Molecularly Defined Midbrain Circuit Mechanism for Sound‐Driven Defensive Behavior and Anxiety

Advanced Science, EarlyView.
Schematic diagram showing the Cbln2+ ICx–dPAG circuit for sound‐driven defensive and anxiety‐like behaviors. ABSTRACT The innate defense behaviors in response to threatening sounds play a fundamental role in survival. However, the neural circuits that detect threat‐relevant auditory cues and transform them into defensive behaviors remain poorly defined.
Jie Cao, Xingxing Lai, Lifang Huo, Zhouyuan Zheng, Qian Zhang, Zhimin Ye, Panpan Wan, Chao Ma, Congping Shang   +8 more
wiley   +1 more source

Galactokinase 1 Positively Regulates Mitochondrial Respiration by Phosphorylating TIMM13 as a Protein Kinase

Advanced Science, EarlyView.
GALK1 acts as a protein kinase beyond the phosphorylation of galactose. GALK1 phosphorylates TIMM13 at Y73 in the cytoplasm. This phosphorylation prevents premature oxidative folding of TIMM13 and ensures its entrance into the intermembrane space of mitochondrion, positively regulating mitochondrial respiration.
Chang Woo Ko, Dongyoon Shin, Junho Park, June Huh, Youngsoo Kim, Jong‐Wan Park   +5 more
wiley   +1 more source

Universal newborn hearing screening

Saudi Medical Journal, 2003
Hearing loss is an "invisible" handicap. If detection is delayed or denied, significant speech, language, social and emotional delay may result. Delayed identification of hearing loss in children will lead to missing a lot of sound input which can in turn affect their communication, learning, behavior and emotional development as well as future ...
openaire   +2 more sources

Vestibular infant screening–Flanders : what is the most appropriate vestibular screening tool in hearing-impaired children?

, 2023
Objectives:As children with sensorineural hearing loss have an increased risk for vestibular impairment, the Vestibular Infant Screening-Flanders project implemented a vestibular screening by means of cervical vestibular evoked myogenic potentials (cVEMP)
Maes, LeenGE37UZGent0019981421038010018278020000-0001-6090-5512F7067E4E-F0ED-11E1-A9DE-61C894A0A6B4, Dhooge, IngeborgGE34UZGent8010008783130000-0002-5915-1079F4A8B1EE-F0ED-11E1-A9DE-61C894A0A6B4, Martens, SarieCA800001005509078020027639308400011845250000-0001-6172-36062CFBD472-F0EE-11E1-A9DE-61C894A0A6B4, Vanaudenaerde, SaartjeUZGent0000904522949791685105262095A3CA-F0EE-11E1-A9DE-61C894A0A6B4, Van Hecke, RuthGE370001204570248020026493480000-0002-6428-890X072A19A6-F0EF-11E1-A197-91C894A0A6B4, Dhondt, Cleo0000905879938020021908229744323927680000-0002-2066-61712328D058-F0EE-11E1-A9DE-61C894A0A6B4, Van Hoecke, HelenGE34UZGent0019960496308020006816620000-0003-1012-021X00097A28-F0EE-11E1-A9DE-61C894A0A6B4, Rombaut, LotteUZGent0000602544779723327057120992FFF6-F0EE-11E1-A9DE-61C894A0A6B4, Sucaet, MariekeUZGent000090504636802002759583977223147537249389F6-F0EE-11E1-A9DE-61C894A0A6B4, De Leenheer, ElsGE34UZGent8020000108470000-0002-2789-3529F841462C-F0ED-11E1-A9DE-61C894A0A6B4   +9 more
core  

WFS1 Deficiency Impairs PIAS4‐Associated SUMOylation and Increases Ubiquitin‐Mediated Spermatogenesis‐Related Protein Degradation Leading to Testicular Male Infertility

Advanced Science, EarlyView.
The findings establish a critical role for WFS1 in human male fertility. Mechanistically, WFS1 interacts with PIAS4 to promote the SUMOylation of key spermatogenesis‐associated proteins, which in turn competitively inhibits their K48‐linked ubiquitin‐mediated degradation during spermatogenesis.
Yunchuan Tian, Guicheng Zhao, Xiang Wang, Xinyao Tang, Gan Shen, Tiechao Ruan, Chuan Jiang, Shikun Zhao, Jincheng Zhang, Xinyue Cui, Liangchai Zhuo, Jun Ma, Yihong Yang, Tingting Lin, Ying Shen   +14 more
wiley   +1 more source

A Universal Newborn Hearing Screening in Iran

Iranian Rehabilitation Journal, 2007
Objectives: In September 2002 University of Social Welfare & Rehabilitation Sciences established a pilot universal newborn hearing screening program in two crowded maternity hospital in Tehran.
Younes Lotfi, Gita Movallali
doaj  

Prevalence of hearing loss among school-age children in Metropolitan Bangkok

BMC Public Health
Background Hearing is essential for communication, social interaction, and learning. Approximately 1 in 500 newborns have congenital hearing loss, with the prevalence being higher in low- and middle-income countries.
Rada Dara, Angkana Lertpoompunya, Maliwan Tammasaeng, Pitchulee Uayporn, Jitpakorn Pichaitanaporn   +4 more
doaj   +1 more source