Results 101 to 110 of about 13,663,771 (328)
The Reconstruction of Peripheral Auditory Circuit: Recent Advances and Future Challenges
Advanced Science, EarlyView.This paper summarizes the potential of biomaterials, stem cells, and gene editing technologies in the regeneration of inner ear hair cells, spiral ganglion neurons, and inner ear organoids. Challenges and potential developments are discussed and explored.
Zhe Li +3 more
wiley +1 more source
Rational Design of Inner Ear Drug Delivery Systems
Advanced Science, EarlyView.Hearing loss is a common disease affecting many people, and inner ear lesions are one of the most important causes. This review focuses on the treatment of inner ear hearing loss by drug delivery systems. It includes the current methods and technologies developed, and it predicts possible directions.
Xiayidan Maimaitikelimu +5 more
wiley +1 more source
Advanced Science, EarlyView.Nonsyndromic orofacial clefts (NSOFCs) are the most common craniofacial defects. Exome sequencing of 214 sporadic cases sheds new light on its genetic architecture and identifies many candidate pathogenic variants. Furthermore, functional studies establish BOC as a novel causal gene and reveal an unusual two‐locus model of inheritance via the epistatic
Qing He +16 more
wiley +1 more source
Brazilian Journal of Otorhinolaryngology, 2013 A resolução temporal permite identificação de pequenas diferenças acústicas nos aspectos segmentais da fala e pode ser avaliada por meio do Random Gap Detection Test (RGDT) e Gaps-In-Noise Test (GIN), os quais possuem diferentes parâmetros acústicos ...
Maria Isabel Ramos do Amaral +2 more
doaj
Industrial Deafness. Hearing Testing and Noise Measurement [PDF]
, 1958 H. D. Paviere
openalex +1 more source
Advanced Science, EarlyView.The TALENTs randomized controlled trial evaluates the potential of nucleotides supplementation as an anti‐aging intervention in older adults. After 19 weeks, nucleotides supplementation significantly reduces DNA methylation age, suggesting a delay in epigenetic aging, and improves insulin sensitivity without severe adverse events.
Shuyue Wang +9 more
wiley +1 more source
Interference Pattern Caused by Bilateral Bone Conduction Stimulation Impairs Sound Localization
Advanced Science, EarlyView.This work explores how crosstalk‐induced wave interference affects bone conduction (BC) sound localization. Using a theoretical model, cadaveric vibrometry, and psychoacoustic tests, atypical BC lateralization patterns are revealed that contradict air conduction (AC) principles.
Liu‐Jie Ren +7 more
wiley +1 more source
Advanced Science, EarlyView.We demonstrate that Foxp1± mice, modeling FOXP1 haploinsufficiency, exhibit behavioral deficits, striatal neuroinflammatory changes including altered microglial complexity and synaptic pruning, and markedly reduced Pde10a expression. Pde10a inhibition starting immediately after birth restores Foxp1± behavior, microglial morphology, and pruning ...
Henning Fröhlich +8 more
wiley +1 more source