Results 161 to 170 of about 844,515 (334)

Rational Design of Metal–Organic Frameworks for Pancreatic Cancer Therapy: from Machine Learning Screening to In Vivo Efficacy

Advanced Materials, EarlyView.
This work explores the MOF landscape to select a single, optimal candidate for successfully delivering cancer drugs (gemcitabine, paclitaxel, SN‐38) into tough pancreatic tumors. Machine learning and simulations guide this search, demonstrating colloidal stability, excellent biocompatibility, cellular uptake, and sustained release.
Francesca Melle, Dhruv Menon, João Conniot, Jon Ostolaza‐Paraiso, Sergio Mercado, Jhenifer Oliveira, Xu Chen, Bárbara B. Mendes, João Conde, David Fairen‐Jimenez   +9 more
wiley   +1 more source

Composable Strategy Framework with Integrated Video-Text based Large Language Models for Heart Failure Assessment [PDF]

arXiv
Heart failure is one of the leading causes of death worldwide, with millons of deaths each year, according to data from the World Health Organization (WHO) and other public health agencies. While significant progress has been made in the field of heart failure, leading to improved survival rates and improvement of ejection fraction, there remains ...
arxiv  

Engineering CAR‐T Therapeutics for Enhanced Solid Tumor Targeting

Advanced Materials, EarlyView.
CART cell therapy has proven effective for blood cancers but struggles with solid tumors due to diverse antigens and complex environments. Recent efforts focus on improving CAR design and validation platforms. Advances in protein engineering, machine learning, and organoid systems aim to enhance CAR‐T therapy against solid tumors.
Danqing Zhu, Won Joon Kim, Hyunjin Lee, Xiaoping Bao, Pilnam Kim   +4 more
wiley   +1 more source

Association between atherogenic index of plasma and physical dysfunction: a cross-sectional study of middle-aged and older adults in China

Frontiers in Public Health
BackgroundPhysical dysfunction is common in older adults and increases disease risk. The atherogenic index of plasma (AIP) is a promising biomarker for this condition.
Jianghui Zhou, Jianghui Zhou, Jianghui Zhou, Jianghui Zhou, Jianghui Zhou, Yun Chang, Yun Chang, Yun Chang, Yun Chang, Hechen Shen, Hechen Shen, Hechen Shen, Hechen Shen, Hechen Shen, Meng Zhang, Meng Zhang, Meng Zhang, Meng Zhang, Meng Zhang, Yuchao Wang, Yuchao Wang, Yuchao Wang, Yuchao Wang, Yuchao Wang, Xiaoyu Liang, Xiaoyu Liang, Xiaoyu Liang, Xiaoyu Liang, Wenqing Gao, Wenqing Gao, Wenqing Gao, Wenqing Gao, Wenqing Gao   +32 more
doaj   +1 more source

Bubbly cloud dynamics and cavitation [PDF]

, 2007
In many cavitating liquid flows, when the number and concentration of the bubbles exceeds some critical level, the flow becomes unsteady and large clouds of cavitating bubbles are periodically formed and then collapse when convected into regions of ...
Brennen, Christopher E.
core  

Advancements in Understanding the Physicochemical Properties of Reticular Materials: An In Situ and Operando Spectroscopic Perspective

Advanced Materials, EarlyView.
This review explores how in situ and operando spectroscopic techniques reveal the real‐time behavior of reticular materials, including MOFs and COFs. These methods track material formation and functionalization, structural changes, defect formation, dynamic responses to external triggers, and catalytic processes.
Bettina Baumgartner, Anna Wach, Xinwei Ye, Evelyn Ploetz, Bert M. Weckhuysen   +4 more
wiley   +1 more source

Artificial Heart Valve Scaffold Based on Electrospun PCL/PU Three-Layer Composite Fibers

Applied Sciences
Abnormal heart valve function is a major cause of heart disease and is often associated with high rates of morbidity and mortality from heart disease.
Xu Gao, Zhong Liu, Zhiwei Zhang, Yuan Gao, Jun Zhang, Yunze Long   +5 more
doaj   +1 more source

Computation of incompressible viscous flows through artificial heart devices with moving boundaries [PDF]

The extension of computational fluid dynamics techniques to artificial heart flow simulations is illustrated. Unsteady incompressible Navier-Stokes equations written in 3-D generalized curvilinear coordinates are solved iteratively at each physical time ...
Chang, I.-DEE, Kiris, Cetin, Kwak, Dochan, Rogers, Stuart   +3 more
core   +1 more source

Comparing the effect of using normal saline, N-acetyl cysteine and not using them in endotracheal tube suction on physiologic parameters and the amount of secretions in intubated patients under mechanical ventilation [PDF]

, 2014
Aims: Today a large number of patients hospitalized in Intensive Care Unit need mechanical ventilation via an artificial air way. Since these patients have endotracheal tube, endotracheal suctioning is necessary for increasing oxygenation, cleaning the ...
Akbaryan Deheki, N., Amri, P., Jouybari, L., Moghaddam, S., Nasiri, H., Sanagoo, A., Vakili, M.A.   +6 more
core  

Van Der Waals Hybrid Integration of 2D Semimetals for Broadband Photodetection

Advanced Materials, EarlyView.
Advanced broadband photodetector technologies are essential for military and civilian applications. 2D semimetals, with their gapless band structures, high mobility, and topological protection, offer great promise for broadband PDs. This study reviews the latest advancements in broadband PDs utilizing heterostructures that combine 2D semimetals with ...
Xue Li, Kunxuan Liu, Di Wu, Pei Lin, Zhifeng Shi, Xinjian Li, Longhui Zeng, Yang Chai, Shu Ping Lau, Yuen Hong Tsang   +9 more
wiley   +1 more source