Results 51 to 60 of about 311,027 (339)

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Durable Continuous-Flow Mechanical Circulatory Support: State of the Art

Hearts, 2021
Implantable mechanical circulatory support (MCS) systems for ventricular assist device (VAD) therapy have emerged as an important strategy due to a shortage of donor organs for heart transplantation.
Antonio Loforte, Luca Botta, Silvia Boschi, Gregorio Gliozzi, Giulio Giovanni Cavalli, Carlo Mariani, Sofia Martin Suarez, Davide Pacini   +7 more
doaj   +1 more source

Heart transplantation in a patient with left ventricular assist device after pump thrombosis: The first case report in Serbia [PDF]

Vojnosanitetski Pregled, 2020
Introduction. The device thrombosis is one of the most serious complications of the left ventricle assist device implantation with a high mortality and morbidity rate. Case report.
Terzić Duško, Putnik Svetozar, Nestorović Emilija, Bilbija Ilija, Gojkovic-Bukarica Ljiljana, Jovičić Vladimir, Rajković Jovana, Ristić Miljko   +7 more
doaj   +1 more source

Diffusion‐based size determination of solute particles: a method adapted for postsynaptic proteins

FEBS Open Bio, EarlyView.
We present a diffusion‐based approach for measuring the size of macromolecules and their complexes, and demonstrate its use on postsynaptic proteins. The method requires fluorescein‐labelled protein samples, a microfluidic device that maintains laminar flow for said samples, a microscope recording the emitted fluorescent signals, and an analytic ...
András László Szabó, Eszter Nagy‐Kanta, Soma Varga, Edit Andrea Jáger, Csaba István Pongor, Mária Laki, András József Laki, Zoltán Gáspári   +7 more
wiley   +1 more source

Rotary mechanical circulatory support systems

, 2017
A detailed survey of the current trends and recent advances in rotary mechanical circulatory support systems is presented in this paper. Rather than clinical reports, the focus is on technological aspects of these rehabilitating devices as a reference ...
Bonnell, Mark, Elahinia, Mohammad, Gupta, Rajesh, Hosseinipour, Milad   +3 more
core   +1 more source

The impact of Hnrnpl deficiency on transcriptional patterns of developing muscle cells

FEBS Open Bio, EarlyView.
We performed nanopore whole‐transcriptome sequencing comparing RNA from Hnrnpl‐knockdown versus control C2C12 myoblasts to investigate the contributions of Hnrnpl to muscle development. Our results indicate that Hnrnpl regulates the expression of genes involved with Notch signaling and skeletal muscle, particularly splicing patterns of specific muscle ...
Hannah R. Littel, Mekala Gunasekaran, Audrey L. Daugherty, Natalya M. Wells, Johnnie Turner, Christine C. Bruels, Christina A. Pacak, Isabelle Draper, Peter B. Kang   +8 more
wiley   +1 more source

Cutting the Cord: A Case of Late Presenting Driveline Infection [PDF]

, 2020
Ventricular assist device (VAD) related infection, specifically driveline infection, is a common complication after VAD implantation. A 45-year old patient with a delayed skin infection at the site of the original driveline nearly one year after VAD ...
Eyadiel, Lauren, Laughey, Brian, Pisani, Barbara   +2 more
core   +1 more source

Enhancing performance during inclined loaded walking with a powered ankle-foot exoskeleton [PDF]

, 2014
A simple ankle-foot exoskeleton that assists plantarflexion during push-off can reduce the metabolic power during walking. This suggests that walking performance during a maximal incremental exercise could be improved with an exoskeleton if the ...
De Clercq, Dirk, Derave, Wim, Galle, Samuel, Malcolm, Philippe   +3 more
core   +2 more sources

Translating a Preclinically Tested 15 Hz rTMS Protocol to Humans With Chronic Spinal Cord Injury: A Safety and Feasibility Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Repetitive transcranial magnetic stimulation (rTMS) is a non‐invasive brain stimulation strategy with a demonstrated potential to reinforce the residual pathways after a spinal cord injury (SCI). A preclinically tested high‐frequency (15 Hz) rTMS (15 Hz rTMS) protocol was shown to induce corticospinal tract axon regeneration growth ...
Nabila Brihmat, Mehmed B. Bayram, Morgan Paine, Janelle Carnahan, Jian Zhong, Xiaofei Guan, Guang H. Yue, Soha Saleh, Gail F. Forrest   +8 more
wiley   +1 more source

Treatment of heart failure with autologous skeletal myoblasts [PDF]

, 2002
The management of patients with heart failure is a daily challenge for cardiologists and cardiac surgeons. Pharmacotherapy, atrio-biventricular resynchronization, myocardial revascularization, valve repair techniques, latissimus dorsi cardiomyoplasty,
Blanchard, D. (D.), Carpentier, A. (A.), Cattadori, B. (B.), Chachques, J. (J.), Fabiani, J.N. (J.N.), Herreros, J. (Jesús), Prosper, F. (Felipe), Trainini, J. (Jorge)   +7 more
core