Results 181 to 190 of about 56,070 (265)

Pediatric Developmental Safety Assessment: Are We Ready for the Next Thalidomide?

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Pediatric drug development has achieved remarkable success in the last 20 years with over 1,000 products studied in pediatric patients. This success has been driven in part by an increased understanding of pediatric disease processes. The aspect that has been largely overlooked is the potential adverse effect of new drugs on pediatric developmental ...
Gilbert J. Burckart   +6 more
wiley   +1 more source

Role of SoxE transcription factors in development and disease

open access: yesDevelopmental Dynamics, EarlyView.
Abstract Sox8, Sox9, and Sox10 arose by multiple rounds of genome duplications from a single SoxE gene in ancestral vertebrates. In this review, we will briefly discuss the molecular structure and function of SoxE transcription factors and their evolutionary origin. We will then discuss their expression, function, and developmental disorders.
Merin Lawrence, Gerhard Schlosser
wiley   +1 more source

Early and Mid-Term Results of Solid Organ Transplantation After Circulatory Death: A 4-Year Single Centre Experience. [PDF]

open access: yesMedicina (Kaunas)
Galeone A   +13 more
europepmc   +1 more source

All‐in‐One Intelligent Hemostatic Sponge: Rapid Hemostasis for Non‐Compressive Wounds With Synergetic Enhanced Antibacterial Efficacy and Self‐Reporting Biodegradation

open access: yesENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
Clinicians often concurrently tackle critical challenges including emergency hemorrhage, secondary infection, and the elusive tracking of biodegradation of conventional hemostatic agents for complex wounds. Here, we report an intelligent hemostatic sponge (spCS@AIE) by incorporating aggregation‐induced emission (AIE) nanoparticles with short‐wave ...
Zhicheng Liu   +12 more
wiley   +1 more source

The utility of the trans-splenic retrocardiac view in supine critically ill patients. [PDF]

open access: yesWorld J Emerg Med
Cheong I   +2 more
europepmc   +1 more source

Bioactive Magnesium Silicate Activating Myocardial Energy Metabolism For Infarcted Myocardium Repair

open access: yesExploration, EarlyView.
ABSTRACT The heart is a highly energy‐dependent organ, developing bioenergy‐activating biomaterials to activate myocardial adenosine triphosphate (ATP) production and restore dysregulated energy homeostasis is a promising solution for its functional recovery.
Zhibin Liao   +11 more
wiley   +1 more source

Disease classification via interpretable machine learning based on multi-center routine coagulation test. [PDF]

open access: yesFront Mol Biosci
Dong F   +13 more
europepmc   +1 more source

Coronavirus disease 2019 infection reduces EGFR‐TKI efficacy in non‐small cell lung carcinoma: Real‐world evidence from a multicenter propensity‐matched cohort

open access: yesInternational Journal of Cancer, EarlyView.
What's New? Lung cancer patients with COVID‐19 experience significantly increased risk for severe illness and mortality. However, research addressing the effect of COVID‐19 on non‐small cell lung cancer (NSCLC) patients treated with epidermal growth factor receptor (EGFR)‐tyrosine kinase inhibitors (TKIs) remains unknown.
Wenjie Tang   +13 more
wiley   +1 more source

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