Results 101 to 110 of about 3,539,316 (312)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Cholesterol efflux capacity does not associate with coronary calcium, plaque vulnerability, and telomere length in healthy octogenarians

Journal of Lipid Research, 2018
Several studies have revealed that traditional risk factors are less effective in predicting CVD risk in the elderly, suggesting the need to identify new biomarkers.
Francesca Zimetti, Wladimir M. Freitas, Alessandra M. Campos, Mauricio Daher, Maria Pia Adorni, Franco Bernini, Andrei C. Sposito, Ilaria Zanotti   +7 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Sacred Heart University Magazine, Spring 2014 [PDF]

, 2012
The lead article in this issue is about Sacred Heart University\u27s success in the area of enrollment. This issue also includes a feature on Professor Jonas Zdanys, grants to Biology Professor Barbara Pierce to further her research on migratory birds ...
Sacred Heart University,
core   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

BNP and NT-proBNP in heart failure : benefits and limitations for clinical ractice : data from COACH and other studies [PDF]

, 2006
The diagnostic and prognostic properties of B-type Natriuretic Peptide (BNP) and N-terminal proBNP (NT-proBNP) in patients with heart failure have been well established during the past years.
Hogenhuis, Jochem,
core  

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Significance of Ischemic Heart Disease in Patients with Heart Failure and Preserved, Midrange, and Reduced Ejection Fraction : A Nationwide Cohort Study [PDF]

, 2017
Background - The pathogenic role of ischemic heart disease (IHD) in heart failure (HF) with reduced ejection fraction (HFrEF; EF
Lam, Carolyn S P, Benson, L, Braun, Oscar O.,, Ulf Dahlström, Koh, Angela S., Dahlstrom, U, Tay, Wan Ting,, Koh, Angela S.,, Tay, WT, Lund, LH, Savarese, G,, Benson, Lina, Lund, Lars H, Vedin, O, Benson, Lina,, Dahlstrom, Ulf,, Lund, Lars H.,, Tay, Wan Ting, Ola Vedin, Tiew Hwa Katherine Teng, Gianluigi Savarese, Dahlström, Ulf, Koh, AS, Oscar Ö. Braun, Lam, CSP, Braun, Oscar Ö., Savarese, Gianluigi, Lars H. Lund, Carolyn S.P. Lam, Teng, THK, Braun, OO, Teng, Tiew Hwa Katherine, Wan Ting Tay, Lam, Carolyn S. P.,, Vedin, Ola, Angela S. Koh, Teng, Tiew Hwa Katherine,, Vedin, Ola,, Savarese, Gianluigi,, Lina Benson   +39 more
core   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source