Results 101 to 110 of about 3,534,452 (312)

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Modifiable lifestyle factors and heart failure: A Mendelian randomization study

, 2020
Background: Lifestyle factors may be important targets in the prevention of heart failure. The current knowledge on the relationship between lifestyle factors and heart failure originates mostly from observational studies. The objective of this study was
Handoko, M. Louis, Beulens, Joline W. J.,, Oort, Sabine van,, Handoko, M. Louis,, Beulens, Joline W.J., van Ballegooijen, Adriana J., Larsson, Susanna C., Larsson, Susanna C.,, van Oort, Sabine, Ballegooijen, Adriana J. van,   +9 more
core   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

Celebrating 50 Years Sacred Heart University (Logo)

, 2013
Logo for the 50th anniversary celebrations of Sacred Heart University, 1963 ...
Sacred Heart University,
core  

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Adults with congenital heart disease: the patients' perspective.

Over the last 50 years technical and other advances have resulted in more than 90% of children born with congenital heart disease (CHD) surviving and reaching adulthood.
Lyon, Joy E.
core  

Heart to heart with PCSK9

European Heart Journal, 2021
Kevin Chemello, Ali K Jaafar, Gilles Lambert   +2 more
openaire   +2 more sources

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

Sacred Heart University Magazine, Winter 2001

, 2001
Special issue: Journal of Giving. The Sacred Heart University Journal of Giving is a register of donors to the University for fiscal year July 1, 1999 to June 30 ...
Sacred Heart University,
core  

Vitamin C inhibits endothelial cell apoptosis in congestive heart failure

, 2001
Background - Proinflammatory cytokines like tumor necrosis factor- and oxidative stress induce apoptotic cell death in endothelial cells (ECs). Systemic inflammation and increased oxidative stress in congestive heart failure (CHF) coincide with enhanced ...
Dimmeler, S, Rossig, L, Aicher, A, Haase, A, Freyssinet, JM, Tedgui, A, Hugel, B, Zeiher, AM, Hoffmann, J, Mallat, Z   +9 more
core   +1 more source