Results 1 to 10 of about 2,119,388 (341)

Numerical simulation of electrocardiograms for full cardiac cycles in healthy and pathological conditions [PDF]

arXiv, 2015
This work is dedicated to the simulation of full cycles of the electrical activity of the heart and the corresponding body surface potential. The model is based on a realistic torso and heart anatomy, including ventricles and atria.
Bayés de Luna, Bayés de Luna, Beinart, Bishop, Boulakia, Boulakia, Boulakia, Bourgault, Bueno-Orovio, Buist, Chapelle, Chapelle, Chatterjee, Cohen, Collin, Corrado, Courtemanche, Deng, Ennis, Geuzaine, Harrild, Ho, Ho, Hoekema, Hudsmith, Huiskamp, Huiskamp, Hurtadoa, Jiamsripong, Jiang, Johnson, Keller, Krishnamoorthi, Krueger, Krueger, Lines, Liu, Malmivuo, Martin, Martini, Matsuo, McGuire, Mitchell, Nash, Netter, Nielsen, Ormiston, Potse, Potse, Pullan, Rosner, Sachse, Sovilj, Streeter, Sundnes, Sundnes, Trudel, Wang, Wartak, Wei, Yan, Zwink   +61 more
core   +6 more sources

Effects of Cardiac Structural Remodelling During Heart Failure on Cardiac Excitation – Insights from a Heterogeneous 3D Model of the Rabbit Atria [PDF]

, 2015
Heart failure is a leading cause of morbidity and mortality in the western world. One of the effects of heart failure is the structural remodelling of cardiac tissue, including tissue dilation and development of fibrosis.
Boyett, Mark, Castro, Simon J, Colman, Michael A, Hart, George, Jarvis, Jonathan C, Kottas, Petros, Stephenson, Robert S, Zhang, Henggui   +7 more
core   +4 more sources

Systematic Analysis of Gene Expression Differences between Left and Right Atria in Different Mouse Strains and in Human Atrial Tissue [PDF]

, 2011
Background: Normal development of the atria requires left-right differentiation during embryonic development. Reduced expression of Pitx2c (paired-like homeodomain transcription factor 2, isoform c), a key regulator of left-right asymmetry, has recently ...
Brown, NA, Fabritz, L, Greber, B, Hoffmeier, A, Kahr, PC, Kirchhof, P, Piccini, I, Scheld, HH, Schöler, H   +8 more
core   +3 more sources

Hox genes define distinct progenitor sub-domains within the second heart field [PDF]

, 2011
Much of the heart, including the atria, right ventricle and outflow tract (OFT) is derived from a progenitor cell population termed the second heart field (SHF) that contributes progressively to the embryonic heart during cardiac looping. Several studies
Bertrand, Nicolas, Capecchi, Mario, Dollé, Pascal, Moon, Anne, Niederreither, Karen, Roux, Marine, Ryckebüsch, Lucile, Zaffran, Stéphane   +7 more
core   +1 more source

Tbx20 Is Required in Mid-Gestation Cardiomyocytes and Plays a Central Role in Atrial Development. [PDF]

, 2018
RationaleMutations in the transcription factor TBX20 (T-box 20) are associated with congenital heart disease. Germline ablation of Tbx20 results in abnormal heart development and embryonic lethality by embryonic day 9.5.
Aneas, Ivy, Bogomolovas, Julius, Boogerd, Cornelis J, Chen, Ju, Evans, Sylvia M, Joslin, Amelia C, Montefiori, Lindsey, Nobrega, Marcelo A, Sakabe, Noboru, Sobreira, Debora R, Zhang, Lunfeng, Zhou, Bin, Zhu, Xiaoming   +12 more
core   +2 more sources

A new algorithm to diagnose atrial ectopic origin from multi lead ECG systems - insights from 3D virtual human atria and torso [PDF]

, 2015
Rapid atrial arrhythmias such as atrial fibrillation (AF) predispose to ventricular arrhythmias, sudden cardiac death and stroke. Identifying the origin of atrial ectopic activity from the electrocardiogram (ECG) can help to diagnose the early onset of ...
Alday, Erick A. Perez, Butters, Timothy D., Colman, Michael A., Hancox, Jules C., Higham, Jonathan, Langley, Philip, Workman, Antony J., Zhang, Henggui   +7 more
core   +2 more sources

Atrial fibrillation and electrophysiology in transgenic mice with cardiac-restricted overexpression of FKBP12 [PDF]

, 2019
Cardiomyocyte-restricted overexpression of FK506-binding protein 12 transgenic (αMyHC-FKBP12) mice develop spontaneous atrial fibrillation (AF). The aim of the present study is to explore the mechanisms underlying the occurrence of AF in αMyHC-FKBP12 ...
Ai, Tomohiko, Chang, Po-Cheng, Chen, Hanying, Chen, Peng-Sheng, Fishbein, Michael C., Homsi, Mohamed, Li, Bai-Yan, Lin, Shien-Fong, Liu, Jijia, Liu, Ying, Maruyama, Mitsunori, Pan, Zhenwei, Rubart, Michael, Shou, Weinian, Xiao, Deyong   +14 more
core   +1 more source

Altered excitation-contraction coupling in human chronic atrial fibrillation [PDF]

, 2012
This review focuses on the (mal)adaptive processes in atrial excitation-contraction coupling occurring in patients with chronic atrial fibrillation. Cellular remodeling includes shortening of the atrial action potential duration and effective refractory ...
Grandi, E., Pandit, S.V., Workman, A.J.
core   +1 more source

Detection of C-type natriuretic peptide (CNP) transcript in the rat heart and immune organs [PDF]

, 1993
Previous studies suggested the expression of mRNA, coding for CNP, exclusively in the central nervous system. In the present study, using the polymerase chain reaction (PCR) technique instead of the less sensitive Northern blot hybridization, CNP ...
Gerbes, Alexander L., Nemer, M., Schulz, R., Vollmar, Angelika M.   +3 more
core   +1 more source

Complete atrial-specific knockout of sodium-calcium exchange eliminates sinoatrial node pacemaker activity. [PDF]

, 2013
The origin of sinoatrial node (SAN) pacemaker activity in the heart is controversial. The leading candidates are diastolic depolarization by "funny" current (If) through HCN4 channels (the "Membrane Clock" hypothesis), depolarization by cardiac Na-Ca ...
Alber, Sarah, Goldhaber, Joshua I, Groenke, Sabine, Jordan, Maria C, Karagueuzian, Hrayr S, Lamp, Scott T, Larson, Eric D, Nakano, Atsushi, Nakano, Haruko, Philipson, Kenneth D, Proenza, Catherine, Ren, Xiaoyan, Roos, Kenneth P, Zhang, Rui   +13 more
core   +2 more sources