Results 61 to 70 of about 375,872 (318)

Predictors and long-term outcomes of heart block after transcatheter device closure of perimembranous ventricular septal defect

open access: yesFrontiers in Cardiovascular Medicine, 2022
BackgroundHeart block is the most common and concerning complication associated with transcatheter device closure of perimembranous ventricular septal defect (pmVSD) and its occurrence remains a great challenge for device closure.MethodsBetween June 2002
Diandong Jiang   +9 more
doaj   +1 more source

Targeting PRAME directly or via EZH2 inhibition overcomes retinoid resistance and represents a novel therapy for keratinocyte carcinoma

open access: yesMolecular Oncology, EarlyView.
The study evaluated the function and therapeutic implications of PRAME in basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The findings demonstrate that PRAME impairs keratinocyte differentiation pathways. Furthermore, PRAME impairs anticancer response to retinoid compounds in BCC and SCC cells.
Brandon Ramchatesingh   +6 more
wiley   +1 more source

Remodelamento ventricular na estimulação cardíaca apical do ventrículo direito Ventricular remodeling in right ventricular apical pacing

open access: yesArquivos Brasileiros de Cardiologia, 2007
OBJETIVO: Avaliar a taxa de remodelamento ventricular (RV) e a importância de variáveis clínico-funcionais em pacientes com função cardíaca normal submetidos à estimulação artificial apical do ventrículo direito (VD).
Rodrigo Tavares Silva   +9 more
doaj   +1 more source

ASIC Implementation of Denoising Filters for Pacemakers [PDF]

open access: yesarXiv, 2023
Cardiac Pacemakers are used to regulate the hearts rhythm and prevent abnormal heart beats. Patients undergo a minimal surgery to get the pacemaker implanted in the body, whereas these devices do have their limitations such as battery life, power consumption and integrated circuit area which makes it difficult for elderly and children to undergo this ...
arxiv  

Expression and purification of E140 protein antigen fragments of Plasmodium vivax and Plasmodium berghei for serological assays

open access: yesFEBS Open Bio, EarlyView.
We provide a step‐by‐step guide for producing E140 antigen fragments from Plasmodium berghei (Pb1) and Plasmodium vivax (Pv1). Pb1/Pv1 are expressed in E. coli, solubilized by freeze–thawing, refolded by slow dilution, purified by affinity chromatography (IMAC), then concentrated and subjected to quality control.
Rodolfo Ferreira Marques   +5 more
wiley   +1 more source

Association of temporary complete AV block and junctional ectopic tachycardia after surgery for congenital heart disease

open access: yesAnnals of Pediatric Cardiology, 2015
Aim: Junctional ectopic tachycardia (JET) is a postoperative complication with a mortality rate of up to 14% after surgery for congenital heart disease. This study evaluated the risk factors of JET and explored the association of postoperative temporary ...
Christian Paech   +4 more
doaj   +1 more source

Identification of inhibitors of the Salmonella FraB deglycase, a drug target

open access: yesFEBS Open Bio, EarlyView.
A high‐throughput screen was used to identify inhibitors of Salmonella FraB, a drug target. Characterization of top hits (identified after an additional counter screen) revealed that some triazolidines, thiadiazolidines, and triazolothiadiazoles are mixed‐type inhibitors of FraB.
Jamison D. Law   +6 more
wiley   +1 more source

Block Sparse Multi-lead ECG Compression Exploiting between-lead Collaboration [PDF]

open access: yes, 2018
Multilead ECG compression (MlEC) has attracted tremendous attention in long-term monitoring of the patients heart behavior. This paper proposes a method denoted by block sparse MlEC (BlS MlEC) in order to exploit between-lead correlations to compress the signals in a more efficient way.
arxiv   +1 more source

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

open access: yesFEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi   +2 more
wiley   +1 more source

Application of Unit Time Block Entropy to Fetal Distress Heart Rate [PDF]

open access: yesarXiv, 2006
Recently, multiple time scale characteristics of heart dynamics have received much attention for distinguishing healthy and pathologic cardiac systems. Despite structural peculiarities of the fetal cardiovascular system, the fetal heart rate(FHR) displays multiple time scale characteristics similar to the adult heart rate due to the autorhythmicity of ...
arxiv  

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