Results 61 to 70 of about 5,481,660 (373)

A review of congenital heart block [PDF]

, 2003
Congenital heart block is a rare disorder. It has an incidence of about 1 in 22,000 live births. It may be associated with high mortality and morbidity.
Buyon, Jill P., Duncanson, L.J., Friedman, Deborah M., Glickstein, J.   +3 more
core   +1 more source

Congestive Heart Failure Leads to Prolongation of the PR Interval and Atrioventricular Junction Enlargement and Ion Channel Remodelling in the Rabbit. [PDF]

, 2015
Heart failure is a major killer worldwide. Atrioventricular conduction block is common in heart failure; it is associated with worse outcomes and can lead to syncope and bradycardic death.
Atkinson, AJ, Boyett, MR, Cai, XJ, Corno, AF, Dobrzynski, H, Hart, G, Jarvis, JC, Jones, CB, Lowe, T, Nikolaidou, T, Sardar, R, Stephenson, RS, Withers, PJ, Yanni, J   +13 more
core   +3 more sources

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

FEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao, Qiangbing Yang, Christian J.B. Snijders Blok, Mark A. Daniels, Pieter A. Doevendans, Raymond Schiffelers, Joost P.G. Sluijter, Zhiyong Lei   +7 more
wiley   +1 more source

Cyclic nucleotide signaling as a drug target in retinitis pigmentosa

FEBS Letters, EarlyView.
Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää, Ahmed B. Montaser, Henri Leinonen   +2 more
wiley   +1 more source

Transcatheter heart valve selection and permanent pacemaker implantation in patients with pre-existent right bundle branch block [PDF]

, 2017
Background-Right bundle branch block is an established predictor for new conduction disturbances and need for a permanent pacemaker (PPM) after transcatheter aortic valve replacement.
Abawi, M. (Masieh), Carrié, D. (Didier), de Nicolas, J.M. (Javier Molina-Martin), Dumonteil, N. (Nicolas), Gils, L. (Lennart) van, Jaegere, P.P.T. (Peter) de, Lhermusier, T. (Thibault), Mieghem, N.M. (Nicolas) van, Olivares, R.R. (Ramón Rodriguez), Stella, P.R. (Pieter), Tchetche, D. (Didier)   +10 more
core   +3 more sources

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

Permanent pacemaker implantation without fluoroscopy in a pregnant woman with complete atrioventricular block: A case report [PDF]

, 2016
A 26-year-old pregnant woman in her first trimester presented with progressive fatigue. Her Electrocardiogram showed second degree heart block (Mobitz type II) with intermittent complete heart block.
Arif, Zainab, Chuprun, Dmitry, Elbadawi, Ayman, Rao, Mohan   +3 more
core   +2 more sources

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Consistency of Spectral Hypergraph Partitioning under Planted Partition Model

, 2016
Hypergraph partitioning lies at the heart of a number of problems in machine learning and network sciences. Many algorithms for hypergraph partitioning have been proposed that extend standard approaches for graph partitioning to the case of hypergraphs ...
Dukkipati, Ambedkar, Ghoshdastidar, Debarghya   +1 more
core   +1 more source

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

Molecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova, Dominika Maurencova, Barbora Salovska, Marek Kratky, Tomas Mracek, Zuzana Korandova, Alena Pecinova, Pavla Vasicova, David Rysanek, Ladislav Andera, Ivo Fabrik, Rudolf Kupcik, Pavel Kashmel, Pinky Sultana, Vojtech Tambor, Jiri Bartek, Josef Novak, Marie Vajrychova, Zdenek Hodny   +18 more
wiley   +1 more source