Results 61 to 70 of about 2,868,059 (314)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Sinus of Valsalva Aneurysm Dissecting into Interventricular Septum Compressing RVOT [PDF]

Journal of Clinical and Diagnostic Research, 2018
Aneurysm of sinus of valsalva is a rare disorder. Rupture of sinus of valsalva into the right atria, right ventricle and the left ventricle is more commonly seen.
Nishu Raj, Pallavi Sinha, Neeraj Wadhwa, Sunil Kumar Puri   +3 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Dual Chamber Pacemaker Implant in Coronary Sinus Leading to Several Complications

Diagnostics
Permanent pacemaker implantation is a low-risk procedure. However, complications may occur at a rate of around 4–8%. We present a case where initial implantation resulted in complications that could have been avoided by meticulous assessment of lead ...
Nancy Wassef, Mina Ibrahim, Christine Botrous, Amr Anos, Kai Hogrefe, Janaka Pathiraja   +5 more
doaj   +1 more source

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

Molecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both, Ingrid A. M. Derks, Raphaël Vanleyssem, Marine Leclercq, Najla El Hachem, Pierre Close, Eric Eldering, Marco Vincent Haselager   +7 more
wiley   +1 more source

Postoperative arrhythmia in pediatric intensive care unit

Journal of Pediatric Critical Care
Postoperative arrhythmias are a significant concern in pediatric patients following cardiac surgery, with an incidence ranging from 7.5% to 48%. These arrhythmias, classified into tachyarrhythmias and bradyarrhythmias, can be triggered by multiple ...
Riyan Sukumar Shetty, K. M. Manavi, Balasubramanian Shanmugasundaram, S. Atul Prabhu   +3 more
doaj   +1 more source

Transient complete heart block following catheter ablation of a left lateral accessory pathway

Journal of Arrhythmia, 2019
A 16‐year‐old female with symptomatic Wolff‐Parkinson‐White (WPW) syndrome underwent catheter ablation of a left‐sided lateral accessory pathway. The accessory pathway was eliminated with the first ablation lesion; however, the patient immediately ...
Franz Schweis, Gordon Ho, David E. Krummen, Kurt Hoffmayer, Ulrika Birgersdotter‐Green, Gregory Feld   +5 more
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Memo from Heart Mountain Block Managers' Office to Councilman of Block 12, Shoji Nagumo, August 1, 1944

, 1944
Memorandum of understanding from Heart Mountain Block Mangers Office to Councilman of Block 12, Shoji Nagumo, regarding future appointments to the block manager position.
Heart Mountain Block Chairmen
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