Results 241 to 250 of about 173,062 (307)

ER proteostasis meets mitochondrial function: contact sites as hubs of communication and therapeutic targets

The FEBS Journal, EarlyView.
Proteostasis ensures proper protein folding, modification, and degradation, while its impairment triggers ER stress. Chronic ER stress and maladaptive UPR via the CHOP–ERO1 axis remodel ERMCs, altering calcium signaling and mitochondrial metabolism.
Giorgia Maria Renna, Alessandro Cherubini, Ersilia Varone, Serena Germani, Alice Marrazza, Ester Zito   +5 more
wiley   +1 more source

Ebstein's anomaly with life-threatening arrhythmia: an unusual cardiovascular manifestation of Williams syndrome - a case report. [PDF]

BMC Cardiovasc Disord
Schouw ME, Koopmann TT, Blom NA, Stöger JL, Barge-Schaapveld DQCM, Bökenkamp R.   +5 more
europepmc   +1 more source

Energetic stress in combination with impaired fatty acid oxidation induces sequestration of CoA and adaptation of CoA metabolism

The FEBS Journal, EarlyView.
Computational modelling and in vitro liver cell experiments indicate that medium‐chain acyl‐CoA dehydrogenase (MCAD) deficiency causes an accumulation of (especially medium‐chain) acyl‐CoAs at the cost of free CoA (CoASH). A substantial decrease in CoASH impairs flux through many pathways essential for energy homeostasis.
Ligia Akemi Kiyuna, Christoff Odendaal, Madhulika Singh, Albert Gerding, Miriam Langelaar‐Makkinje, Marianne van der Zwaag, Asmara Drachman, Vladimíra Cetkovská, Gaby Liem Foeng Kioen, Anne‐Claire M. F. Martines, Nicolette C. A. Huijkman, Hein Schepers, Bart van de Sluis, Dirk‐Jan Reijngoud, Ody C. M. Sibon, Amy C. Harms, Thomas Hankemeier, Barbara M. Bakker   +17 more
wiley   +1 more source

New perspectives in the management of adults with congenital heart disease: insights from the 2025 ACHD Congress. [PDF]

Eur Heart J Suppl
Borrelli N, Sabatino J, Ruperti-Repilado FJ, Tutarel O, Giannakoulas G, D'Alto M, Romeo E, Tobler D, Diller GP.   +8 more
europepmc   +1 more source

Unravelling the Genetic Mechanisms of Litter Traits in a Maternal Line of Pigs

Journal of Animal Breeding and Genetics, EarlyView.
ABSTRACT Reproductive traits related to litter size are the main indicators of reproductive efficiency in pig production and are continuously evaluated for the selection of maternal lines. Several environmental and genetic factors are involved with the development of these traits.
Guilherme Oselame, Suelen Fernandes Padilha, Maurício Egídio Cantão, Jane de Oliveira Peixoto, Aline Zampar, Adriana Mércia Guaratini Ibelli, Luis Orlando Duitama Carreño, Jader Silva Lopes, Pedro Henrique Ferreira Freitas, Marcelo Silva Freitas, Mônica Corrêa Ledur   +10 more
wiley   +1 more source

Loss of the maternal effect gene NLRP2 impairs embryonic and extra-embryonic development, revealing a novel genetic cause of congenital anomalies†. [PDF]

Biol Reprod
Sharif M, Anvar Z, Chakchouk I, El-Dessouky SH, Zemet R, Kao EC, Sharaf-Eldin WE, Wan YW, Liu Z, Liu P, Jochum M, Van den Veyver IB.   +11 more
europepmc   +1 more source

Cardiac findings in infants with in utero exposure to Zika virus - a follow up longitudinal study. [PDF]

PLoS Negl Trop Dis
Dang BN, Kikuta K, Fuller T, Brasil P, Vasconcelos Z, Orofino DHG, Moreira MEL, Nielsen-Saines K.   +7 more
europepmc   +1 more source

Analytical validation and clinical evaluation of a high-sensitivity cardiac troponin I immunoassay for use in cats. [PDF]

PLoS One
Lidbury JA, Meyers RC, Saunders AB, Vitt JP, Gordon SG, Lim S, Fries RC, Suchodolski JS, Steiner JM, Wesselowski S.   +9 more
europepmc   +1 more source

Care pathways for pediatric surgical conditions. [PDF]

World J Pediatr Surg
Vuddemarry M, Zadey S, Sp A, Ghosh D, Zheleva B.   +4 more
europepmc   +1 more source

The influence of paternal preconception health on birth defects and head circumference: A scoping review. [PDF]

PLOS Glob Public Health
Dennis CL, McQueen K, Dol J, Dennis-Grantham A, Singla DR, Nkurunziza A, Abbass-Dick J, Birken CS, Shorey S.   +8 more
europepmc   +1 more source