Results 21 to 30 of about 148,895 (244)

Single Administration of AAV‐mAtp6v1b2 Gene Therapy Rescues Hearing and Vestibular Disorders Caused by Atp6v1b2‐Induced Lysosomal Dysfunction in Hair Cells

Advanced Science, EarlyView.
Wei et al. establish a hair cell‐specific conditional knockout mouse model (Atp6v1b2fl/fl;Atoh1Cre/+), and demonstrate the importance of Atp6v1b2 for hair cell through maintaining the survival of lysosomes. A single administration of AAV‐ie‐Eh3‐mAtp6v1b2 through scala media at P0‐P2 realizes function compensation and restores hearing and balance ...
Gege Wei, Shiwei Qiu, Xue Gao, Lu Zheng, Yijin Chen, Ying Ma, Haifeng Feng, Jinyuan Yang, Guojie Dong, Huiyi Nie, Weihao Zhao, Xiaoge Li, Guangqin Wang, Wei Xiong, Pu Dai, Yongyi Yuan   +15 more
wiley   +1 more source

Spectrum of congenital heart defects in Croatia

European Journal of Pediatrics, 2009
The aim of our study was to investigate the incidence of congenital defects in children born in Croatia during a period of 5 years, its association with extracardiac malformations, its treatment, and outcome. Medical information about the patients was obtained from 14 paediatric cardiology centres that cover the whole country.
Dilber, Daniel, Malčić, Ivan
openaire   +5 more sources

A systematic review of trends and patterns of congenital heart disease in children in Nigeria from 1964-2015 [PDF]

, 2016
Background: Congenital heart diseases cause significant childhood morbidity and mortality. Several restricted studies have been conducted on the epidemiology in Nigeria.
Abdulkadir, Mohammed, Abdulkadir, Zainab
core   +2 more sources

Post‐Translational Modifications in Cilia and Ciliopathies

Advanced Science, EarlyView.
This review synthesizes current understanding of post‐translational modifications (PTMs) in ciliary proteins and emphasizes their roles in ciliary formation, homeostasis, and signaling. This review also discusses the implication of PTM dysregulation in ciliopathies and explores therapeutic strategies targeting PTM‐modifying enzymes.
Jie Ran, Jun Zhou
wiley   +1 more source

Injectable and Sprayable Thermoresponsive Hydrogel with Fouling‐Resistance as an Effective Barrier to Prevent Postoperative Cardiac Adhesions

Advanced Science, EarlyView.
Postoperative cardiac adhesions lead to numerous difficulties in reoperation procedures. Here, a thermo‐responsive in situ formed hydrogel is shown to can reliably cover the wounds after a convenient spraying or injection and significantly reduce adhesion formation in primary and recurrent cardiac injury adhesion models.
Kun Shi, Tao Li, Xulin Hu, Wen Chen, Yan Yu, Zhongwu Bei, Liping Yuan, Qi Tong, Jiafeng Liu, Qiang Fan, Yongjun Qian, Zhiyong Qian   +11 more
wiley   +1 more source

A Dutch MYH7 founder mutation, p.(Asn1918Lys), is associated with early onset cardiomyopathy and congenital heart defects [PDF]

, 2017
Background Mutations in the myosin heavy chain 7 (MYH7) gene commonly cause cardiomyopathy but are less frequently associated with congenital heart defects.
Barge-Schaapveld, D.Q.C.M. (Daniela), Bootsma, M. (Marianne), Boven, L.G. (Ludolf), Breuning, M.H. (Martijn), Bökenkamp, A. (Arend), Herkert, J.C. (Johanna), Hiemstra, Y.L. (Y. L.), Jongbloed, J.D.H. (Jan), Lekanne Deprez, R.H., Mil, A.M. (Anneke) van, Ruivenkamp, C.A. (Claudia), Slegtenhorst, M.A. (Marjon) van, Spaendonck-Zwarts, K.Y. (Karin) van, Ten Broeke, S.W. (Sanne W.), van der Linde, I.H.M. (I. H.M.), Veldkamp, R.F. (Rolf), Waning, J. (Jaap) van, Zwaag, P.A. (Paul) van der   +17 more
core   +1 more source

Generation of Neural Organoids and Their Application in Disease Modeling and Regenerative Medicine

Advanced Science, EarlyView.
Neural organoids provide a versatile platform for neurological research. Advances in organoid technology have partially achieved human neural tissue complexity in terms of tissue structure, cell diversity, and neural signaling, offering insights into neural disorders and regenerative strategies. Technology advances from biomaterials, bio‐manufacturing,
Ruiqi Huang, Feng Gao, Liqun Yu, Haokun Chen, Rongrong Zhu   +4 more
wiley   +1 more source

Ventricular Function in Congenital Heart Defects [PDF]

Frontiers in Pediatrics, 2016
In order to understand the physiology of the neonatal heart, one must have an understanding of both the fetal circulation and the cardiac function of the adult heart. Transitional changes occur in the neonatal period, where the function of one ventricle has important effects on the function of the contralateral ventricle (1).
openaire   +3 more sources

Exogenous WNT5A and WNT11 proteins rescue CITED2 dysfunction in mouse embryonic stem cells and zebrafish morphants [PDF]

, 2019
Mutations and inadequate methylation profiles of CITED2 are associated with human congenital heart disease (CHD). In mouse, Cited2 is necessary for embryogenesis, particularly for heart development, and its depletion in embryonic stem cells (ESC) impairs
AC Fahed, AC Michell, B Bamforth, B Li, B Xu, BG Bruneau, C-M Chen, CA Eisenberg, D Fraidenraich, D Sabour, ED Cohen, EY Chen, H Mori, H Thomas, I Pacheco-Leyva, J Bakkers, JA Bisson, JA Gaspar, JP Pinto, JPM Barbera, K Meganathan, KR Kranc, M Sahara, M Xu, MV Kuleshov, P Andre, P Choudhry, P Hu, Q Li, S Bhattacharya, S Liu, S Mazzotta, S Sperling, S Ueno, S Zaidi, S-W Cha, SD Bamforth, ST MacDonald, ST MacDonald, T Tan, V Kouskoff, V Wagh, VK Khodiyar, WJ Weninger, Y Liu, Z Yin   +45 more
core   +1 more source

Large Language Model‐Based Chatbots in Higher Education

Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.
The use of large language models (LLMs) in higher education can facilitate personalized learning experiences, advance asynchronized learning, and support instructors, students, and researchers across diverse fields. The development of regulations and guidelines that address ethical and legal issues is essential to ensure safe and responsible adaptation
Defne Yigci, Merve Eryilmaz, Ail K. Yetisen, Savas Tasoglu, Aydogan Ozcan   +4 more
wiley   +1 more source