Results 21 to 30 of about 93,463 (256)

Development and Validation of the CHDSI Questionnaire: A New Tool for Measuring Disease-Specific Quality of Life in Children and Adolescents with Congenital Heart Defects

Medicina
Background and Objectives: Congenital heart defects (CHD) affect around 1% of the population, making them the most common congenital disease worldwide. Thanks to advances in treatment, over 90% of affected children are able to reach adulthood, shifting ...
Paul C. Helm, Ulrike M. M. Bauer, Peter Ewert, Julia Remmele   +3 more
doaj   +1 more source

New Insights into the Education of Children with Congenital Heart Disease with and without Trisomy 21

Medicina, 2023
Background and Objectives: Patients with congenital heart disease (CHD), especially as a concomitant syndromal disease of trisomy 21 (T21), are at risk for impaired neurodevelopment. This can also affect these patients’ education.
Katharina R. L. Schmitt, Laura K. Sievers, Alina Hütter, Hashim Abdul-Khaliq, Martin Poryo, Felix Berger, Ulrike M. M. Bauer, Paul C. Helm, Constanze Pfitzer   +8 more
doaj   +1 more source

Interventional Partial Cavopulmonary Connection: Initial Clinical Experience With Acute Procedural up to Midterm Results

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Creation of a partial cavopulmonary anasthomosis in patients with isolated right‐sided heart failure or patients with cyanosis and intracardial right‐to‐left shunt and reduced blood flow in the pulmonary circulation may provide a significant ...
Katarzyna Gendera, Peter Ewert, Stanimir Georgiev, Andreas Eicken, Daniel Tanase, Kristina Borgmann, Paul Philipp Heinisch, Nicole Nagdyman, Julie Cleuziou, Dunja Renner, Pinar Bambul Heck   +10 more
doaj   +1 more source

Assessment of anatomy of the aorta in patients with a coarctation of aorta

The Cardiothoracic Surgeon, 2023
Background Coarctation of the aorta (CoA) is a congenital heart disease characterized by the narrowing of the aorta, resulting in reduced blood flow to the body and increased pressure in the left ventricle.
B. B. Turaev, Kh. K. Abralov, B. Kh. Kobiljonov, N. Sh. Ibragimov   +3 more
doaj   +1 more source

Nationwide Survey Reveals High Prevalence of Non-Swimmers among Children with Congenital Heart Defects

Children, 2023
Background: Physical activity is important for children with congenital heart defects (CHD), not only for somatic health, but also for neurologic, emotional, and psychosocial development. Swimming is a popular endurance sport which is in general suitable
Christian Apitz, Dominik Tobias, Paul Helm, Ulrike M. Bauer, Claudia Niessner, Jannos Siaplaouras   +5 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Biointegrated Battery‐Based Electroceuticals

Advanced Materials, EarlyView.
Biointegrated batteries go beyond passive power to serve as active therapeutic platforms for delivering programmable electrical cues and bioactive agents. This review examines their mechanisms and applications and provides a framework to guide battery‐based therapeutic design and clinical translation.
Yan Zhou, Zhilian Yue, Zhiqi Chen, Danming Chao, Xiaoteng Jia, Gordon Wallace, Caiyun Wang   +6 more
wiley   +1 more source

Strategic Design of Soft Actuators in Translational Medical Robotics for Human‐Centered Healthcare

Advanced Robotics Research, EarlyView.
Soft robotics enables biocompatible, compliant medical devices, but clinical translation requires design‐driven engineering beyond materials. This perspective reviews implantable, surgical, and wearable systems by actuation mechanism, highlighting how optimized architectures and integration improve mechanical interfacing, adaptability, and durability ...
Ho Jun Jin, Jimin Kim, Inho Kim, Bong Hoon Kim   +3 more
wiley   +1 more source

Spatio-Temporal Distribution and Demographic Characteristics of Congenital Heart Defects in Guangdong, China, 2016–2020

Frontiers in Public Health, 2022
BackgroundCongenital heart defects are the most common type of birth defects and bring a heavy disease burden in China. Examining the temporal and spatial trends of congenital heart defects epidemics can give some elementary knowledge for succeeding ...
Huazhang Miao, Huazhang Miao, Huazhang Miao, Qinghui Zeng, Zengping Shi, Yi Xia, Lushaobo Shi, Dongxue Chen, Pi Guo, Yingxian Zhu, Dong Wang   +10 more
doaj   +1 more source

Integrative Omics Analysis Reveals the Regulation of Hypoxia Tolerance in Large Yellow Croaker (Larimichthys crocea) via the Lipoic Acid Synthase (lias) Gene

Advanced Science, EarlyView.
Lipoic acid synthase (lias) can regulate α‐KG levels through lipoylation, thereby negatively regulating HIF‐1α protein levels via PHD under hypoixa. The Hap2 allele of lias exhibits lower expression levels than Hap1, leading to the accumulation of more HIF‐1α protein and thereby enhancing hypoxia tolerance. ABSTRACT Hypoxia stress seriously affects the
Jie Ding, Songpeng Jia, Ran Meng, Xuelei Wang, Xiongfei Wu, Weiliang Shen, Yibo Zhang, Junquan Zhu   +7 more
wiley   +1 more source