Results 41 to 50 of about 257,840 (166)

Defects in PDIA4 increase individuals’ susceptibility to congenital heart disease

Frontiers in Genetics
IntroductionCongenital heart disease (CHD) comprises structural abnormalities of the heart and major blood vessels arising during fetal development. Protein disulfide isomerase family member 4 (PDIA4) facilitates protein folding processes.
Yuquan Lu, Yuquan Lu, Jiangjie Liu, Jiangjie Liu, Siyu Sun, Siyu Sun, Zhiyu Feng, Zhiyu Feng, Yuan Gao, Yuan Gao, Shaojie Min, Shaojie Min, Quannan Zhuang, Quannan Zhuang, Siyi Lin, Siyi Lin, Quming Zhao, Quming Zhao, Xianghui Huang, Wei Sheng, Wei Sheng, Wei Sheng, Guoying Huang, Guoying Huang, Guoying Huang   +24 more
doaj   +1 more source

Comparison of Two Measurement Devices for Pulse Wave Velocity in Children: Which Tool Is Useful to Detect Vascular Alterations Caused by Overweight?

Frontiers in Pediatrics, 2019
Vascular alterations may lead to manifest cardiovascular disease in future life. There is a tremendous time delay between the onset and obvious clinical appearance of vascular alterations.
Julia Elmenhorst, Heidi Weberruss, Martina Mayr, Karin Pfister, Renate Oberhoffer, Renate Oberhoffer   +5 more
doaj   +1 more source

Identification of candidate genes harboring pathogenic variants in congenital heart disease and laterality defects in Chinese population

Frontiers in Genetics
ObjectiveCongenital heart disease (CHD) is often accompanied by laterality defects (LD), giving rise to a severe and intricate form of congenital anomaly.
Jinxin Wang, Jinxin Wang, Weicheng Chen, Weicheng Chen, Xianghui Huang, Xianghui Huang, Xianghui Huang, Han Gao, Han Gao, Zhiyu Feng, Zhiyu Feng, Chaozhong Tan, Chaozhong Tan, Quannan Zhuang, Quannan Zhuang, Yuan Gao, Yuan Gao, Shaojie Min, Shaojie Min, Yuquan Lu, Yuquan Lu, Feizhen Wu, Maoxiang Qian, Maoxiang Qian, Weili Yan, Weili Yan, Weili Yan, Wei Sheng, Wei Sheng, Wei Sheng, Wei Sheng, Guoying Huang, Guoying Huang, Guoying Huang, Guoying Huang   +34 more
doaj   +1 more source

How Emotion Regulation and Illness Identity Shape Mental Health in Adults with Congenital Heart Disease

Medical Sciences
Background/Objectives: Adults with congenital heart disease (ACHD) are at increased risk for mental health problems, particularly depression and anxiety. Emerging evidence suggests that psychological rather than purely medical factors may play a decisive
Anna-Lena Ehmann, Daniel T. Marggrander, Janina Semmler, Felix Berger, Paul C. Helm, Constanze Pfitzer   +5 more
doaj   +1 more source

Conotruncal Heart Defects

Majalah Kardiologi Indonesia, 2016
Conotruncal anomalies comprise a diverse group of congenital heart defects involving the outflow tracts of the heart and the great .They are a leading cause symptomatic cyanotic cardiac disease diagnosed in utero.
Herlina Dimiati, Silfia Yasmine Lubis
doaj   +1 more source

Epidemiology of paediatric chronic heart failure in Germany—A population‐based analysis

ESC Heart Failure
Aims Paediatric chronic heart failure (CHF) is associated with significant morbidity. The aim of this study was to describe paediatric CHF epidemiology in Germany.
Alexej Bobrowski, Sven Klebs, Marco Alibone, Leonore Bovy, Dennis Häckl, Thilo Fleck, Brigitte Stiller   +6 more
doaj   +1 more source

Case Report: Heart aneurysm of unknown origin in a two-year-old child diagnosed in the course of Multisystem Inflammatory Syndrome in Children

Frontiers in Cardiovascular Medicine
We present a case of a 22-month-old boy with a hypokinetic and thin-walled aneurysm of the left ventricle apex. The lesion was diagnosed during routine echocardiography examination in the course of MIS-C, and its occurrence due to MIS-C is plausible ...
Dominika Mystkowska, Michal Galeczka, Wojciech Tarala, Pawel Banaszak, Joanna Sliwka, Szymon Pawlak, Roland Fiszer   +6 more
doaj   +1 more source

Commentary: Fontan circulation with lymphatic failure: Was the Holy Grail finally found?Central Message

JTCVS Techniques, 2021
Eugen Sandica, MD
doaj   +1 more source

A cardiac-related, promoter-proximal, regulatory element shapes chromatin and JAG1 transcription

Life Science Alliance
This study identifies R7 as a promoter-proximal element that supports JAG1 transcription by coordinating local chromatin contacts and regulatory features.
Quannan Zhuang, Feng Wang, Huinan Zhang, Qi Zhang, Yuan Gao, Zhiyu Feng, Han Gao, Siyu Sun, Siyi Lin, Shuolin Li, Quming Zhao, Xianghui Huang, Qiang Li, Wei Sheng, Guoying Huang   +14 more
doaj   +1 more source

P53 and mTOR signalling determine fitness selection through cell competition during early mouse embryonic development

Nature Communications, 2018
During embryo development, cell fitness determines survival but how this is regulated is unclear. Here, the authors show that in early embryonic development and stem cells exiting the naive state, cells sense the fitness of their neighbours and trigger ...
Sarah Bowling, Aida Di Gregorio, Margarida Sancho, Sara Pozzi, Marieke Aarts, Massimo Signore, Michael D. Schneider, Juan Pedro Martinez-Barbera, Jesús Gil, Tristan A. Rodríguez   +9 more
doaj   +1 more source