50 years of heart disease in Ireland: mortality, morbidity and health services implications.
, 2000 In 1999, 12,996 people died from vascular diseases in Ireland. In 1950, 11,887 people died from the same group of diseases. The populations of the respective years differed, of course (approximately 4 million vs 2.9 million), and a higher proportion ...
Codd, Mary B. +3 more
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Style of Coping and its Determinants in Adults with Congenital Heart Disease in a Developing Country
, 2014 Objective The objective of this study is to compare coping strategies between adults with and without congenital heart disease and to scrutinize the associations between different available resources (e.g., social support) and adoption of certain coping ...
Soares, Joaquim J. F., +6 more
core +1 more source
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
Irish Heart Foundation position statement on salt, blood pressure and heart disease [PDF]
, 2004 stroke and related diseases of blood vessels.1, 2 CVD the single largest cause of death in Ireland 3. There is now convincing evidence that sodium intake, mainly through dietary salt (sodium chloride), is directly associated with blood pressure. 1,2, 4,
Irish Heart Foundation (IHF)
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Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer
Aging and Cancer, EarlyView.Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss +12 more
wiley +1 more source
Review of acute rheumatic fever and rheumatic heart disease among Indigenous Australians [PDF]
, 2013 This review is intended to provide an authoritative, up-to-date account of acute rheumatic fever and rheumatic heart disease among Indigenous people.PrefaceThis review of acute rheumatic fever and rheumatic heart disease among Indigenous Australians ...
Caitlin Gray, Neil Thomson
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Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
Position paper on physical activity for children and young people
, 2001 The National Heart Alliance is an independent non-governmental organisation which aims to increase co-operation among organisations involved in the fight against heart disease. ➢ The National Heart Alliance includes representation from a wide range of
National Heart Alliance
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Evidence based cardiology - Psychosocial factors in the aetiology and prognosis of coronary heart disease: systematic review of prospective cohort studies [PDF]
, 1999 Summary points: In healthy populations, prospective cohort studies show a possible aetiological role for type A/hostility (6/14 studies), depression and anxiety (11/11 studies), psychosocial work characteristics (6/10 studies), social support (5/8 ...
Marmot, M., Hemingway, H.
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Sex Representation in US Stroke Clinical Trials: A Decade of Trends and Challenges
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Stroke remains a major cause of disability and mortality in the US, with significant sex‐based disparities, and females remain underrepresented in stroke clinical trials. We aimed to examine sex representation in US‐based stroke clinical trials, identify trial characteristics associated with higher female enrollment (≥ 50%), and ...
Chaitali Dagli +5 more
wiley +1 more source