Results 191 to 200 of about 1,754,517 (342)

Soft Pneumatic Device Designed to Mimic the Periosteal Environment for Regulating the Fate of Mesenchymal Stem Cells

open access: yesAdvanced Healthcare Materials, EarlyView.
This study presents a custom‐made soft pneumatic device (SPD) that mimics complex mechanical forces and fluid flow to enhance in vitro cell differentiation. It shows that low mechanotransduction promotes MSC differentiation into osteoprogenitor cells, while high mechanotransduction causes structural disruptions and cell detachment, providing new ...
Gwang‐Bum Im   +9 more
wiley   +1 more source

Living Microalgae‐Based Magnetic Microrobots for Calcium Overload and Photodynamic Synergetic Cancer Therapy

open access: yesAdvanced Healthcare Materials, EarlyView.
A magnetic microrobot fabricated by Spirulina platensis is proposed to accumulate in tumor regions and generate in situ high calcium concentration and sufficient oxygen. These characteristics of the microrobot present a strategy for triggering calcium overload therapy and chlorophyll‐mediated photodynamic therapy, and such combination resulted in a ...
Shuai Jiang   +12 more
wiley   +1 more source

Missed or Delayed Diagnosis of Heart Disease by the General Pediatrician. [PDF]

open access: yesChildren (Basel)
Karatza AA   +6 more
europepmc   +1 more source

3D Microtumors Representing Ovarian Cancer Minimal Residual Disease Respond to the Fatty Acid Oxidation Inhibitor Perhexiline

open access: yesAdvanced Healthcare Materials, EarlyView.
Minimal residual disease (MRD) leads to cancer relapse and poor survival in ovarian cancer. The lack of representative 3D models limits therapy development. The microfluidics‐based high throughput 3D microtumor platform described here generates clinically‐relevant MRD models. The 3D microtumors recapitulate the molecular signatures of MRD from patients.
Xingyun Yang   +14 more
wiley   +1 more source

Anti-inflammatory Therapies for Ischemic Heart Disease. [PDF]

open access: yesCurr Cardiol Rep
Muhs T, Ljubojevic-Holzer S, Sattler S.
europepmc   +1 more source

A Novel 3D High‐Throughput Phenotypic Drug Screening Pipeline to Identify Drugs with Repurposing Potential for the Treatment of Ovarian Cancer

open access: yesAdvanced Healthcare Materials, EarlyView.
Ovarian cancer's high recurrence and therapy resistance demand new strategies. A high‐throughput drug screening pipeline using 3D spheroids, which showed poor concordance with 2D models, identified rapamycin as a promising candidate. In combination with cisplatin, rapamycin demonstrated significant in vitro and in vivo efficacy, highlighting the ...
Nazanin Karimnia   +9 more
wiley   +1 more source

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