Results 21 to 30 of about 3,197,237 (262)

CONGENITAL HEART DISEASE: Heart disease and pregnancy [PDF]

Heart, 2001
Pregnancy in most women with heart disease has a favourable maternal and fetal outcome. With the exception of patients with Eisenmenger syndrome, pulmonary vascular obstructive disease, and Marfan syndrome with aortopathy, maternal death during pregnancy in women with heart disease is rare.1-4 However, pregnant women with heart disease do remain at ...
Jack M. Colman, Samuel C. Siu
openaire   +3 more sources

Do patients with suspected heart failure and preserved left ventricular systolic function suffer from "diastolic heart failure" or from misdiagnosis? A prospective descriptive study [PDF]

, 2000
OBJECTIVES: To characterise the clinical features of patients with suspected heart failure but preserved left ventricular systolic function to determine if they have other potential causes for their symptoms rather than being diagnosed with 'diastolic ...
Caruana, L., Davie, A.P., McMurray, J., Petrie, M.C.   +3 more
core   +2 more sources

Limitations of adjustment for reporting tendency in observational studies of stress and self reported coronary heart disease [PDF]

, 2002
Recently, observational evidence has been suggested to show a causal association between various "psychosocial" exposures, including psychological stress, and heart disease. Much of this evidence derives from studies in which a self reported psychosocial
Carroll, D., Davey Smith, G., Hart, C., Heslop, P., Macleod, J., Metcalfe, C.   +5 more
core   +2 more sources

Association of plasma uric acid with ischaemic heart disease and blood pressure: mendelian randomisation analysis of two large cohorts [PDF]

, 2013
Objectives: To assess the associations between both uric acid levels and hyperuricaemia, with ischaemic heart disease and blood pressure, and to explore the potentially confounding role of body mass index. Design: Mendelian randomisation analysis, using
Benn, Marianne, Lawlor, Debbie A., Nordestgaard, Børge G., Palmer, Tom M., Smith, George Davey, Timpson, Nicholas J., Tybjærg-Hansen, Anne   +6 more
core   +1 more source

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence

FEBS Letters, EarlyView.
Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek, Ariane Fischer, Mariano Ruz Jurado, Anita Tamiato, Tara Procida‐Kowalski, Jochen Wilhelm, Dennis Hecker, Maximilian Merten, Felicitas Escher, Badder Kattih, Valentina Puntmann, David John, Marcel H. Schulz, Eike Nagel, Stefanie Dimmeler, Guillermo Luxán   +15 more
wiley   +1 more source

Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis

FEBS Letters, EarlyView.
Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner, Juthamas Khamseekaew, M. Gregor Madej, Linda Geiges, Bardha Azemi, Christine Ziegler, Christoph Korbmacher, Alexandr V. Ilyaskin   +7 more
wiley   +1 more source

Women, men and coronary heart disease: a review of the qualitative literature [PDF]

, 2005
Aim. This paper presents a review of the qualitative literature which examines the experiences of patients with coronary heart disease. The paper also assesses whether the experiences of both female and male patients are reflected in the literature and ...
Annandale E., Clark A.M., Craig J., Crane P.B., Daly J., Dempsey S.J., Department of Health, Doyal L., Ford J.S., Furze G., Gardner K., Healy B., Helpard H., Higgins M., Hunt J.M., Johnson J.L., Keaton K.A., Keller C., Khaw K.-T., LaCharity L.A., Levy S.M., Lidell E., Mackay J., McKinlay J.B., McSweeney J.C., Miller C.L., Pattenden J., Patterson J.M., Richards H.M., Richards H.M., Rogers A.E., Ruston A., Scherck K.A., Schofield T., Schwartz J.M., Sharp I., The Scottish Office, Thomas D.J., Tobin B., Tod A.M., Treloar C., Webster R., White A., White A., Zuzelo P.R.   +44 more
core   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

Recognising anxiety and post-traumatic stress disorder in cardiac patients [PDF]

, 2010
Research has established that anxiety and post-traumatic stress disorder (PTSD) are risk factors for the development of heart disease in healthy populations.
Ayers, S., Copland, C., Joekes, K.
core