Results 71 to 80 of about 13,894,413 (409)

Cyclic nucleotide signaling as a drug target in retinitis pigmentosa

FEBS Letters, EarlyView.
Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää, Ahmed B. Montaser, Henri Leinonen   +2 more
wiley   +1 more source

Performance of an active fixation bipolar left ventricular lead vs passive fixation quadripolar leads in cardiac resynchronization therapy, a randomized trial

Journal of Arrhythmia, 2021
Background Usage of active fixation bipolar left ventricular (LV) leads represents an alternative approach to the more commonly used passive fixation quadripolar leads in cardiac resynchronization therapy (CRT).
Havard Keilegavlen, Peter Schuster, Thomas Hovstad, Svein Faerestrand   +3 more
doaj   +1 more source

Progress Toward Achieving National Targets for Reducing Coronary Heart Disease and Stroke Mortality: A County‐Level Perspective

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background The American Heart Association and Healthy People 2020 established objectives to reduce coronary heart disease (CHD) and stroke death rates by 20% by the year 2020, with 2007 as the baseline year.
Adam S. Vaughan, Rebecca C. Woodruff, Christina M. Shay, Fleetwood Loustalot, Michele Casper   +4 more
doaj   +1 more source

Heart disease and stroke statistics--2008 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee.

Circulation, 2007
1. About These Statistics…e70 2. Cardiovascular Diseases…e72 3. Coronary Heart Disease, Acute Coronary Syndrome, and Angina Pectoris…e89 4. Stroke…e99 5. High Blood Pressure…e111 6. Congenital Cardiovascular Defects…e116 7.
W. Rosamond, K. Flegal, K. Furie, A. Go, K. Greenlund, Nancy Haase, S. Hailpern, Michael Ho, V. Howard, B. Kissela, S. Kittner, D. Lloyd‐Jones, M. McDermott, J. Meigs, C. Moy, G. Nichol, Christopher J O'Donnell, V. Roger, P. Sorlie, J. Steinberger, T. Thom, M. Wilson, Yuling Hong   +22 more
semanticscholar   +1 more source

Recognising anxiety and post-traumatic stress disorder in cardiac patients [PDF]

, 2010
Research has established that anxiety and post-traumatic stress disorder (PTSD) are risk factors for the development of heart disease in healthy populations.
Ayers, S., Copland, C., Joekes, K.
core  

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

A rapid deployment valve option for failing Medtronic Freestyle full root: a single centre experience

Journal of Cardiothoracic Surgery
Background There are several high-risk treatment options for valve failure of a biological full root replacement. When tailoring the best treatment option for the patient, implantation of a rapid deployment valve (RDV) should be considered.
Solveig Moss Kolseth, Sahrai Saeed, Pirjo-Riitta Salminen, Vegard Skalstad Ellensen, Venny Lise Kvalheim, Abukar Mohamed Ali, Rune Haaverstad   +6 more
doaj   +1 more source

Scleroderma Heart Disease

International Journal of Immunopathology and Pharmacology, 2005
Heart disease is a frequent and often severe feature of systemic sclerosis (scleroderma). Cardiomyopathy, with ventricular diastolic dysfunction and arrhythmias, is the most important form, since it is associated with a very poor prognosis. The current challenge is to define its pattern and identify individuals at risk, but evaluation in vivo may be ...
B. Marasini, M. Massarotti, R. Cossutta
openaire   +4 more sources

Association of plasma uric acid with ischaemic heart disease and blood pressure: mendelian randomisation analysis of two large cohorts [PDF]

, 2013
Objectives: To assess the associations between both uric acid levels and hyperuricaemia, with ischaemic heart disease and blood pressure, and to explore the potentially confounding role of body mass index. Design: Mendelian randomisation analysis, using
Benn, Marianne, Lawlor, Debbie A., Nordestgaard, Børge G., Palmer, Tom M., Smith, George Davey, Timpson, Nicholas J., Tybjærg-Hansen, Anne   +6 more
core   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source