A simplified, co‐culture‐free protocol for kidney organoids that generate segmented nephrons, including collecting ducts, has been developed. Early low‐dose RA with FGF9 induces balanced anterior–posterior IM patterning and dual UE/MM lineage commitment. BMP7 enhances nephron progenitor maturation.
Jung Hwa Lim +13 more
wiley +1 more source
Response to "Letter to the editor related to the article "Trends in mortality due to ischemic heart diseases among patients with Alzheimer's disease in the United States from 1999 to 2020. International journal of cardiology. Cardiovascular risk and prevention, 25, 200390″. [PDF]
Akhtar M, Nabi R, Ahmed R.
europepmc +1 more source
Design rules are presented to control intestinal organoid polarity in fully synthetic hydrogels. The laminin‐derived IKVAV sequence is crucial to obtain correct intestinal organoid polarity. Increasing hydrogel dynamics further supports the growth of correctly polarized intestinal organoids, while a bulk level of stiffness (G’ ≈ 0.7 kPa) is crucial to ...
Laura Rijns +10 more
wiley +1 more source
[The association between biological aging markers and valvular heart diseases]. [PDF]
Liu X +5 more
europepmc +1 more source
This work presents a “tooth‐on‐chip” device that mimics dental pulp tissue. By co‐culturing key cell types, it recreates vascular networks, stem cell niches, the odontoblast/dentine interface, and trigeminal innervation. This innovative platform provides a unique model of dental pulp structure and physiology, with significant potential for accelerating
Alessandro Cordiale +6 more
wiley +1 more source
A report study of successful surgical treatment of an aorto-left ventricular tunnel in a 5-year-old boy: differential diagnosis from other congenital heart diseases with similar clinical symptoms. [PDF]
Yaghoubi Golverdi A +7 more
europepmc +1 more source
A stable composite pH sensor is developed by coating graphene oxide (GO) nanosheets with covalent organic frameworks (COFs) to improve stability and sensitivity in acidic environments. The GO/COFs sensor demonstrates high selectivity, linearity, and biocompatibility, offering a promising strategy for continuous pH monitoring in gastro‐esophageal reflux
Ahmed H. M. Salem +6 more
wiley +1 more source
Loop diuretics in heart failure: The objective markers to guide the therapy are needed
Jan Biegus +2 more
doaj +1 more source
Cardiac macrophages in maintaining heart homeostasis and regulating ventricular remodeling of heart diseases. [PDF]
Kang M +7 more
europepmc +1 more source

