Results 211 to 220 of about 66,290,039 (265)

Biventricular Pressure‐Volume Loop Analysis in an LVAD Patient Optimized With Impella RP Flex

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Right ventricular (RV) failure after left ventricular assist device (LVAD) implantation is a serious complication which may necessitate temporary mechanical support in refractory cases. Here we describe a 63‐year‐old man with end‐stage ischemic cardiomyopathy and severe combined pre‐ and post‐capillary pulmonary hypertension who developed ...
Sara S. Inglis, Serena Rahme, Andrew N. Rosenbaum, Atta Behfar   +3 more
wiley   +1 more source

Delivering Quadruple Therapy for Heart Failure With Reduced Ejection Fraction in a Customizable Polypill: The COMBO-HF-X Pilot Randomized Trial. [PDF]

JACC Heart Fail
DeJong C, Durstenfeld MS, Davis JD, Wang CS, Riley ED, Huffman MD, Hickey MD, Shade SB, Chen JC, Kazi DS, Grochowski J, Steward WT, Zier LS, Sandhu AT, Heidenreich PA, Agarwal A, Hsue PY.   +16 more
europepmc   +1 more source

Diagnostic Agreement and Threshold Correspondence Between Resting Full‐Cycle Ratio and Nicorandil‐Based Fractional Flow Reserve in Intermediate Coronary Stenosis: A Prospective Single‐Center Registry

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background RFR has shown good aggregate agreement with FFR, including in prior Asian cohorts using intracoronary nicorandil. Where RFR‐FFR disagreement is concentrated relative to the FFR 0.80 decision boundary, and how the two binary thresholds correspond, remain incompletely characterized. Methods In a prospective single‐center registry, 300
Yonghoon Shin, Onyou Kim, Gi Won Yu, Yun Won Lee, Jung‐Joon Cha, Hyung Joon Joo, Jae Hyoung Park, Soon Jun Hong, Cheol Woong Yu   +8 more
wiley   +1 more source

Association between human leukocyte antigen-DQ2/DQ8 positivity and incident atrial fibrillation in patients with heart failure with reduced ejection fraction. [PDF]

Rev Assoc Med Bras (1992)
Küçük U, Akşit E.
europepmc   +1 more source

UMOD Genotype and Clinical Outcomes in Heart Failure Patients Treated with Loop Diuretics: A UK Biobank Pharmacogenetic Cohort Study

Clinical Pharmacology &Therapeutics, EarlyView.
Uromodulin (UMOD) regulates tubular sodium handling and modulates NKCC2, the molecular target of loop diuretics (LD). Although UMOD variants have been associated with blood pressure and hypertension, their pharmacogenetic relevance in heart failure (HF) remains unknown.
Reinhold Kreutz, Pimrapat Gebert, Jingwen Luo, Paraskevi Tassopoulou, Juliane Bolbrinker, Antonios Douros   +5 more
wiley   +1 more source

Development and Evaluation of a Clinical Prediction Model for Acute Kidney Injury Risk in Elderly Patients with Heart Failure with Reduced Ejection Fraction. [PDF]

Glob Heart
Yang R, Song Q, Ma H, Fan Y, Lin S, Liang T, Chen J, Tan N, Jiang L.   +8 more
europepmc   +1 more source

Enhancing Evidence Generation by Linking Randomized Clinical Trials to Real‐World Data: The INVESTED‐Medicare Linkage Study

Clinical Pharmacology &Therapeutics, EarlyView.
Real‐world evidence (RWE) derived from real‐world data (RWD) can complement randomized controlled trials (RCTs), yet the validity of RWD relative to RCT data remains insufficiently characterized. We obtained post hoc consent and linked individual participant data from the US‐based INVESTED trial (2016–2019) with Medicare fee‐for‐service claims (2012 ...
Hanseul Cho, HoJin Shin, Mehdi Najafzadeh, Brian Claggett, Janinne Ortega‐Montiel, Jun Liu, Julie M. Paik, Narlina F. Lalani, Marie C. Bradley, John Concato, Scott D. Solomon, Orly Vardeny, Elisabetta Patorno   +12 more
wiley   +1 more source

Conduction system vs. biventricular pacing in heart failure with reduced ejection fraction: a meta-analysis of randomized controlled trials. [PDF]

Europace
Karakasis P, Vlachos K, Siontis KC, Cano Ó, Tzeis S, Strik M, Pamporis K, Leventopoulos G, Antoniadis AP, Jaïs P, Burri H, Fragakis N.   +11 more
europepmc   +1 more source

In Silico Clinical Trials in Drug Development: Virtual Patients, Applications, and Regulatory Convergence

Clinical Pharmacology &Therapeutics, EarlyView.
Conventional clinical trials remain the benchmark for evaluating therapeutic safety and efficacy, yet they are constrained by escalating costs, withdrawal over the extended follow‐up periods, recruitment difficulties, ethical limits, and a restricted ability to characterize heterogeneous populations.
Maximilian Balmus, Sheng‐Ya Wang, Edward W. G. Ashton, Rosie K. Barrows, Molly Monks, Yuzhang Ge, Arthur Lefebvre, Steven A. Niederer   +7 more
wiley   +1 more source

Dynamic cracking properties and generating conditions of coal under rapid gas release

Deep Underground Science and Engineering, EarlyView.
Gas release tests revealed that crack initiation and propagation are jointly controlled by initial crack length, residual strength, and gas release velocity. A new outburst risk coefficient was thus developed from a fracture mechanics perspective, offering a novel predictive approach.
Bing Zhang, Hanpeng Wang, Liang Yuan, Guofeng Yu, Wei Wang, Benliang Chen, Bo Ren   +6 more
wiley   +1 more source