Results 51 to 60 of about 540,797 (310)

Changes in Liver Function Tests, Congestion, and Prognosis After Acute Heart Failure

JACC: Advances
Background: Elevated alanine aminotransferase (ALT), aspartate aminotransferase (AST), and total bilirubin (tBil) may reflect congestion and liver dysfunction in acute heart failure (AHF), while lower ALT also associates with sarcopenia.
Peder L. Myhre, MD, PhD, Avishay Grupper, MD, Alexandre Mebazaa, MD, PhD, Beth Davison, PhD, Christopher Edwards, BSc, Koji Takagi, MD, Marianna Adamo, MD, Mattia Arrigo, MD, Marianela Barros, MD, Jan Biegus, MD, PhD, Jelena Celutkiene, MD, PhD, Kamilė Čerlinskaitė-Bajorė, MD, Ovidiu Chioncel, MD, PhD, Alain Cohen-Solal, MD, PhD, Albertino Damasceno, MD, PhD, Benjamin Deniau, MD, PhD, Rafael Diaz, MD, Gerasimos Filippatos, MD, Etienne Gayat, MD, PhD, Antoine Kimmoun, MD, PhD, Jozine M. ter Maaten, MD, PhD, Marco Metra, MD, PhD, Maria Novosadova, MD, Matteo Pagnesi, MD, Peter S. Pang, MD, Piotr Ponikowski, MD, PhD, Hadiza Saidu, MBBS, Karen Sliwa, MD, PhD, Daniela Tomasoni, MD, Adriaan Voors, MD, PhD, Gad Cotter, MD, Carolyn S.P. Lam, MD, PhD   +31 more
doaj   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Any heart failure treatments associated with worsening renal function in patients admitted due to acute heart failure?

Renal Failure, 2021
Background Worsening renal function (WRF) occurs in approximately 25% of acute heart failure patients, and both baseline characteristics and heart failure treatment may increase the risk of WRF.
Chutatip Limkunakul, Benjawan Srisantithum, Yotin Lerdrattanasakulchai, Thanakorn Laksomya, Jatuphorn Jungpanich, Kittisak Sawanyawisuth   +5 more
doaj   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Prevalence and clinical significance of liver function abnormalities in patients with acute heart failure

Biomedical Papers, 2015
Aims: Liver pathology caused by cardiac dysfunction is relatively well recognized, however, its clinical importance has not been fully evaluated. The aim of this study was to assess the prevalence of liver function tests (LFTs) abnormalities and to ...
Klaudia Vyskocilova, Lenka Spinarova, Jindrich Spinar, Tereza Mikusova, Jiri Vitovec, Josef Malek, Filip Malek, Ales Linhart, Marian Fedorco, Petr Widimsky, Cestmir Cihalik, Jiri Parenica, Simona Littnerova, Jiri Jarkovsky   +13 more
doaj   +1 more source

Impact of Sacubitril/Valsartan on surfactant binding proteins, central sleep apneas, lung function tests and heart failure biomarkers: Hemodynamic or pleiotropism? [PDF]

, 2022
Massimo Mapelli, Irene Mattavelli, Elisabetta Salvioni, Cristina Banfi, Stefania Ghilardi, Fabiana De Martino, Paola Gugliandolo, Valentina Mantegazza, Valentina Volpato, Christian Basile, Inês Pires, Valentina Sassi, Benedetta Nusca, Carlo Vignati, Mauro Contini, Chiarella Sforza, Maria Luisa Biondi, Pasquale Perrone Filardi, Piergiuseppe Agostoni   +18 more
openalex   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source