Results 51 to 60 of about 564,711 (266)

Changes in Liver Function Tests, Congestion, and Prognosis After Acute Heart Failure

JACC: Advances
Background: Elevated alanine aminotransferase (ALT), aspartate aminotransferase (AST), and total bilirubin (tBil) may reflect congestion and liver dysfunction in acute heart failure (AHF), while lower ALT also associates with sarcopenia.
Peder L. Myhre, MD, PhD, Avishay Grupper, MD, Alexandre Mebazaa, MD, PhD, Beth Davison, PhD, Christopher Edwards, BSc, Koji Takagi, MD, Marianna Adamo, MD, Mattia Arrigo, MD, Marianela Barros, MD, Jan Biegus, MD, PhD, Jelena Celutkiene, MD, PhD, Kamilė Čerlinskaitė-Bajorė, MD, Ovidiu Chioncel, MD, PhD, Alain Cohen-Solal, MD, PhD, Albertino Damasceno, MD, PhD, Benjamin Deniau, MD, PhD, Rafael Diaz, MD, Gerasimos Filippatos, MD, Etienne Gayat, MD, PhD, Antoine Kimmoun, MD, PhD, Jozine M. ter Maaten, MD, PhD, Marco Metra, MD, PhD, Maria Novosadova, MD, Matteo Pagnesi, MD, Peter S. Pang, MD, Piotr Ponikowski, MD, PhD, Hadiza Saidu, MBBS, Karen Sliwa, MD, PhD, Daniela Tomasoni, MD, Adriaan Voors, MD, PhD, Gad Cotter, MD, Carolyn S.P. Lam, MD, PhD   +31 more
doaj   +1 more source

Baroreflex Dysfunction in Prader Willi Syndrome [PDF]

Journal of Clinical and Diagnostic Research, 2016
Prader-Willi syndrome is a classical hypothalamic insufficiency disorder. This syndrome is often associated with cardiovascular morbidity and mortality - which could probably be attributed to autonomic dysfunction.
Manpreet Kaur, Shival Srivastav, Ashok Kumar Jaryal, Kishore Kumar Deepak   +3 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

The circulatory reaction to graduated work as a test of the heart's functional capacity [PDF]

Experimental Biology and Medicine, 1915
The valuable aid to diagnosis, prognosis, and treatment which an accurate test of the heart's functional capacity would afford has made it the object of much clinical research, and although a number of tests have been devised, the validity of each has been seriously questioned and no one has met with general acceptance.
openaire   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Challenges in the Management of Thyrotoxicosis Associated with Atrial Fibrillation and Heart Failure: Two Case Reports

Clinical Medicine Insights: Case Reports, 2021
Background: Thyrotoxicosis is a clinical syndrome with high amounts of free thyroid hormone levels causing elevated thyroid hormone function in body tissues.
Abid M Sadiq, Nyasatu G Chamba
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source