Results 41 to 50 of about 1,900,908 (289)

Traumatic cardiac injury: Experience from a level-1 trauma centre

Chinese Journal of Traumatology, 2016
Purpose: Traumatic cardiac injury (TCI) is a challenge for trauma surgeons as it provides a short therapeutic window and the management is often dictated by the underlying mechanism and hemodynamic status.
Biplab Mishra, Amit Gupta, Sushma Sagar, Maneesh Singhal, Subodh Kumar   +4 more
doaj   +1 more source

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

Effects of low and high intensity exercises on serum mean values of myoglobin and heart-type fatty acid-binding protein in athletes [PDF]

, 2010
Mehdikhani M. Effects of low and high intensity exercises on serum mean values of myoglobin and heart-type fatty acid-binding protein in athletes. Bielefeld (Germany): Bielefeld University; 2010.In current study we reviewed some muscle injury markers ...
Mehdikhani, Majid
core  

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Splenic Injuries at Bugando Medical Centre in Northwestern Tanzania: A Tertiary Hospital Experience. [PDF]

, 2012
Splenic injuries constitute a continuing diagnostic and therapeutic challenge to the trauma or general surgeons practicing in developing countries where sophisticated imaging facilities are either not available or exorbitantly expensive.
Gilyoma Japhet M, Mabula D Mchembe, Giiti, Geofrey, Alphonce B Chandika, Gilyoma, Japhet M, Chandika Alphonce B, Dass Ramesh M, Chalya, Phillipo L, McHembe, Mabula D, Phillipo L Chalya, Chalya Phillipo L, Joseph B Mabula, Dass, Ramesh M, Giiti Geofrey, Mchembe Mabula D, Chandika, Alphonce B, Geofrey Giiti, Ramesh M Dass, Japhet M Gilyoma, Mabula, Joseph B, Mabula Joseph B   +20 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Impaired mitophagy at the heart of injury [PDF]

Autophagy, 2011
Recent publications link mitophagy mediated by PINK1 and Parkin with cardioprotection and attenuation of inflammation and cell death. The field is in need of methods to monitor mitochondrial turnover in vivo to support the development of new therapies targeting mitochondrial turnover.
Roberta A, Gottlieb, Robert M, Mentzer, Phyllis-Jean, Linton   +2 more
openaire   +2 more sources

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Management of Accidental and Iatrogenic Foreign Body Injuries to Heart- Case Series [PDF]

Journal of Clinical and Diagnostic Research, 2017
Accidental and iatrogenic foreign body injuries to heart require immediate attention and its timely management is cornerstone to the life of an individual.
RUPESH KUMAR, SANDEEP SINGH RANA, SANJAY KUMAR, DEEPANWITA DAS, MONALISA DATTA   +4 more
doaj   +1 more source