Results 71 to 80 of about 1,785,309 (311)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Bone mechanical loading reduces heart rate and increases heart rate variability in mice

Bone Reports
Cardiovascular disease and osteoporosis are clinically associated. Bone adapts to mechanical forces by altering its overall structure and mass. In response to mechanical strain bone cells release signaling molecules and activate the nervous system.
Julian A. Vallejo, Mark Gray, Jackson Klump, Andrew Wacker, Mark Dallas, Mark L. Johnson, Michael J. Wacker   +6 more
doaj   +1 more source

Under Pressure? A Study of Heart Rate and Heart-Rate Variability Using SmarTerp

Hermes, 2023
The results of a quasi-experimental, intra-subject study are reported on the effects of the use of SmarTerp on physiological stress levels of twelve second-year students of the MA in Interpreting at the University of Bologna during a simultaneous ...
Christian, Nicoletta Spinolo, Ricardo Muñoz Martín   +2 more
doaj  

National survey of the prevalence, incidence, primary care burden, and treatment of heart failure in Scotland [PDF]

, 2004
Objective: To examine the epidemiology, primary care burden, and treatment of heart failure in Scotland, UK. Design: Cross sectional data from primary care practices participating in the Scottish continuous morbidity recording scheme between 1 April ...
McMurray, J., McMurray, JJV, Capewell, S, Murphy, NF, Simpson, C. R., Chalmers, J, Kirkpatrick, M, Simpson, CR, McAlister, F., Chalmers, J., Redpath, A., McAlister, F.A., Murphy, N. F., McMurray, J. J. V., Simpson, C.R., MacIntyre, K., Capewell, S., Stewart, S., McAlister, FA, MacIntyre, K, McAlister, F. A., Murphy, N.F., Murphy, N., Kirkpatrick, M., Redpath, A, Simpson, C., Stewart, S   +26 more
core   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

The Association Between Endurance Training and Heart Rate Variability: The Confounding Role of Heart Rate [PDF]

, 2018
Heart rate variability (HRV) is a widely used marker of cardiac autonomic nervous activity (CANA). Changes in HRV with exercise training have often been interpreted as increases in vagal activity. HRV is strongly associated with heart rate, which in turn,
Matthias Wilhelm, Nicolas Brugger, Wilhelm, Matthias, Prisca Eser, Herzig, David, Babken Asatryan, Asatryan, Babken, Brugger, Nicolas Jacques, David Herzig, Eser, Prisca   +9 more
core   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Heart Rate Slowing by If Current Inhibition /

, 2006
This book unfolds the history of the discovery of the transmembrane channel which is responsible for the ‘funny’ or If current, the primary modulator of heart rate.
Camm, A.J.
core  

Influence of transrectal and transabdominal ultrasound examination on salivary cortisol, heart rate, and heart rate variability in mares

, 2015
Pregnancy diagnostics in equine reproduction are routinely performed using transrectal ultrasonography, although it is also possible to visualize the fetus by transabdominal ultrasound examinations from the 90th day of gestation onward.
Sieme, Harald, Piechotta, Marion, Martinsson, Gunilla, Hopster-Iversen, Charlotte, Schönbom, Hanno, Kassens, Ana, Klewitz, Jutta, Burger, Dominik, Kißler, Andreas   +8 more
core   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source