Results 101 to 110 of about 8,735,065 (335)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Computationally Efficient Estimation of Heart Rate from PPG Signals

Algerian Journal of Signals and Systems
Heart rate (HR) monitoring using photoplethysmographic (PPG) signals is becoming increasingly popular due to the simplicity of device design and the low cost of wearable technology.
Salah FERDI, Fayçal ABDELLICHE
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Heart rate dependency of JT interval sections. [PDF]

, 2017
BACKGROUND: Little experience exists with the heart rate correction of J-Tpeak and Tpeak-Tend intervals. METHODS: In a population of 176 female and 176 male healthy subjects aged 32.3±9.8 and 33.1±8.4years, respectively, curve-linear and linear ...
Marek Malik, Vicente, J, Johannesen, L, Malik, M, Lars Johannesen, Hnatkova, K, Katerina Hnatkova, Jose Vicente   +7 more
core   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Statistical Machine Learning for Automatic Assessment of Physical Activity Intensity Using Multi-axial Accelerometry and Heart Rate [PDF]

, 2011
This work explores the automatic recognition of physical activity intensity patterns from multi-axial accelerometry and heart rate signals. Data collection was carried out in free-living conditions and in three controlled gymnasium circuits, for a total ...
Chausa Fernández, Paloma, Enrique J. Gómez, Gómez, Enrique J., Benito, Pedro José, García Sáez, Gema, Pedro José Benito, Hernando Pérez, María Elena, Gema García-Sáez, García-García, Fernando, Fernando García-García, M. Elena Hernando, Gómez Aguilera, Enrique J., Martínez-Sarriegui, Iñaki, Garcia Garcia, Fernando, Paloma Chausa, Chausa, Paloma, Benito Peinado, Pedro José, Iñaki Martínez-Sarriegui, Martínez Sarriegui, Iñaki, Hernando, M. Elena, García-Sáez, Gema   +20 more
core   +1 more source

Vision-Based Measurement of Heart Rate from Ballistocardiographic Head Movements Using Unsupervised Clustering

Sensors, 2019
Heart rate has been measured comfortably using a camera without the skin-contact by the development of vision-based measurement. Despite the potential of the vision-based measurement, it has still presented limited ability due to the noise of ...
Hyunwoo Lee, Ayoung Cho, Seongwon Lee, Mincheol Whang   +3 more
doaj   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Influence of transrectal and transabdominal ultrasound examination on salivary cortisol, heart rate, and heart rate variability in mares [PDF]

, 2015
Pregnancy diagnostics in equine reproduction are routinely performed using transrectal ultrasonography, although it is also possible to visualize the fetus by transabdominal ultrasound examinations from the 90th day of gestation onward.
Sieme, Harald, Piechotta, Marion, Martinsson, Gunilla, Hopster-Iversen, Charlotte, Schönbom, Hanno, Kassens, Ana, Klewitz, Jutta, Burger, Dominik, Kißler, Andreas   +8 more
core   +1 more source

Purification and preparation of Marchantia polymorpha Auxin Response Factor 2 for phase separation studies

FEBS Open Bio, EarlyView.
We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen, Robin Romein, Willy A. M. van den Berg, Simon Lindhoud, Jan Willem Borst, Carlo P. M. van Mierlo   +5 more
wiley   +1 more source