Results 221 to 230 of about 4,481,103 (333)

Multi-level feature encoding algorithm based on FBPSI for heart sound classification. [PDF]

Sci Rep
Fang Y, Leng H, Wang W, Liu D.
europepmc   +1 more source

Optimal model‐based design of experiments for parameter precision: Supercritical extraction case

The Canadian Journal of Chemical Engineering, EarlyView.
Abstract This study investigates the process of chamomile oil extraction from flowers. A parameter‐distributed model consisting of a set of partial differential equations is used to describe the governing mass transfer phenomena in a cylindrical packed bed with solid chamomile particles under supercritical conditions using carbon dioxide as a solvent ...
Oliwer Sliczniuk, Pekka Oinas
wiley   +1 more source

Automated analysis of heart sound signals in screening for structural heart disease in children. [PDF]

Eur J Pediatr
Papunen I, Ylänen K, Lundqvist O, Porkholm M, Rahkonen O, Mecklin M, Eerola A, Kallio M, Arola A, Niemelä J, Jaakkola I, Poutanen T.   +11 more
europepmc   +1 more source

Pharmacokinetic Evaluation of a Cinnamon Product on CYP2A6 Substrate Drugs: Application of a Novel Tool Involving the Nicotine Metabolite Ratio

Clinical Pharmacology &Therapeutics, EarlyView.
Cinnamon (Cinnamomum spp.) is used as a culinary spice and dietary supplement. A major constituent, cinnamaldehyde, was previously shown to inactivate cytochrome P450 (CYP) 2A6 in vitro. A mechanistic static model predicted an ~5‐fold increase in the AUC of the CYP2A6 substrates nicotine and letrozole.
Aiden‐Hung P. Nguyen, Deena L. Hadi, Daniel A. Todd, Preston K. Manwill, John R. White, Matthew E. Layton, Nadja B. Cech, Kenneth E. Thummel, Mary F. Paine   +8 more
wiley   +1 more source

Enhanced heart sound anomaly detection via WCOS: a semi-supervised framework integrating wavelet, autoencoder and SVM. [PDF]

Front Neuroinform
Zeng P, Kang S, Fan F, Liu J.
europepmc   +1 more source

Heart Sounds and Murmurs [PDF]

Circulation, 1964
openaire   +2 more sources

More Than a Question of Correlation: Characterization of the Evidentiary Basis for Biomarker Surrogates Used in European Marketing Authorizations

Clinical Pharmacology &Therapeutics, EarlyView.
Traditionally, clinical outcomes measuring how a patient feels, functions, or survives are preferred endpoints in clinical trials; however, some may take a long time to manifest in slowly developing diseases. Biomarkers, if properly validated, can serve as surrogate endpoints, acting as substitutes for clinical outcomes.
Renske Johanna Grupstra, Viktoriia Starokozhko, Elisabeth Bakker, Anna Maria Gerdina Pasmooij, Peter Gerardus Maria Mol   +4 more
wiley   +1 more source

Correlations between heart sound components and hemodynamic variables. [PDF]

Sci Rep
Park YS, Kim HS, Lee SA, Hwang GS, Jung W, Moon B, Kang KM, Seo WY, Song JG, Kim SH.   +9 more
europepmc   +1 more source

The Heart as an Ocean exploring meaningful interaction with biofeedback [PDF]

, 2008
Correia da Silva Diniz, Nuno, Coussement, Pieter, Demey, Michiel, Leman, Marc   +3 more
core  

A Comparison of Regional Decisions for Doses and Administrations of New Drugs: Concordance, Discordance, and Dependencies

Clinical Pharmacology &Therapeutics, EarlyView.
Regional differences in approved drug dosages and administration are shaped by complex factors, including clinical data, prior regulatory decisions, and region‐specific considerations. This study investigated how such factors are associated with variations in approved doses across the United States Food and Drug Administration (FDA), European Medicines
Sachiko Mita, Shunsuke Ono
wiley   +1 more source