Results 91 to 100 of about 1,952,025 (296)

Prognosis of alternative therapies in patients with heart failure not accepted for heart transplantation

, 1995
This article describes the outcome of alternative therapies in patients with end-stage heart failure, New York Heart Association class III-IV, referred for heart transplantation evaluation but not accepted for the procedure.
Lindelöw, B, Waagstein, Finn,, Bergh, Claes-Håkan,, Andersson, Bert,   +3 more
core  

Ionizable Lipid‐Dependent Optimization of Steroid Lipid Nanoparticles With Tunable Immunomodulatory Properties

Advanced Materials, EarlyView.
A novel engineering strategy that establishes material design principles for incorporating anti‐inflammatory steroids into lipid nanoparticles to reduce LNP‐induced inflammation while retaining mRNA delivery. Results are validated in vitro and in three animal models of inflammation and autoimmunity in vivo.
Ajay S. Thatte, Benjamin E. Nachod, Julia Baena, Jenna Muscat‐Rivera, Lesley Chaboub, Hannah C. Safford, Hannah C. Geisler, Hannah M. Yamagata, Melgious J. Y. Ang, Michael Kegel, Alexandre Poirier, Elaine R. Tong, Zhe Zhong, Qiangqiang Shi, Jinjin Wang, Elisa Battistini, Ye Zeng, Alex G. Hamilton, Kelsey L. Swingle, Drew Weissman, Jilian R. Melamed, Michael J. Mitchell   +21 more
wiley   +1 more source

From Fiber Bundles to Architected Membranes: Triply Periodic Minimal Surface Architectures for Biohybrid Artificial Lungs

Advanced Materials, EarlyView.
Additively manufactured triply periodic minimal surface (TPMS) membranes offer an architecture‐driven alternative to hollow fiber bundles in artificial lungs. Multiphysics simulations and endothelialized prototypes show that the 3D‐printable membrane architecture improves gas exchange, blood flow distribution, and hemocompatibility, enabling ...
Michael Pflaum, Kai P. Barbian, Florian Neuhaus, Gerrit Sitarz, Carolin Nölke, Sebastian V. Jansen, John Linkhorst, Lukas T. Hirschwald, Sebastian Brosch, Christian Certa, Ulrich Steinseifer, Matthias Wessling, Jutta Arens, Arjang Ruhparwar, Bettina Wiegmann   +14 more
wiley   +1 more source

Quadriceps Strength Predicts Estimates of Physical Activity Post Heart Transplantation

, 2017
We know that exercise capacity improves post-heart transplantation, yet it remains unclear how physically active patients are once recovered post-surgically.
Kelly, RL, McKenzie, S, Morris, NR, S.T. Yerkovich, Kelly, R. L., Yerkovich, ST, R.L. Kelly, McKenzie, S., Yerkovich, S. T., J.R. Walsh, J.D. Paratz, N.R. Morris, Walsh, JR, S. McKenzie, Paratz, JD, Paratz, J. D., Walsh, J. R., Morris, N. R.   +17 more
core   +1 more source

Self‐Assembling Copolymers Encapsulating Single Endothelial Cells Induce Endogenous ECM Deposition and Vascular Regeneration

Advanced Materials, EarlyView.
This study presents the first demonstration of stable sub‐50‐micron single‐cell GPM vesicles fabricated through the intrinsic self‐assembly of an amphiphilic copolymer. Hierarchical assembly of cell containing GPM vesicles into microspheres enable tunable, sustained cell delivery with immune protection.
Viola B. Morris, Sangho Lee, Kalp Soni, Simon He, Matthew Huang, Dandan Chen, Dae Hoon Lee, Kyung Hee Kim, Seonggeon Cho, Laura Pencea, Divit Jain, Young‐Sup Yoon   +11 more
wiley   +1 more source

Allosensitization and outcomes in pediatric heart transplantation

, 2011
Allosensitization among children being considered for heart transplantation remains a great challenge. Controversy exists as to the best approach for those with elevated panel-reactive antibody (PRA) titers.
Rusconi, Paolo, William T. Mahle, James F. George, Margaret A. Tresler, David C. Naftel, Naftel, David C, George, James F, Shaddy, Robert E, R. Erik Edens, Mahle, William T, Paolo Rusconi, Edens, R. Erik, Robert E. Shaddy, Tresler, Margaret A   +13 more
core   +1 more source

3D‐Printed Corneal Substitutes: Materials, Fabrication, and Preclinical Progress

Advanced Materials Technologies, EarlyView.
Successful clinical translation of 3D‐printed corneal substitutes relies on the interplay between the bioink properties, cellular component, and the fabrication process. These factors influence the critical properties of the construct, including optical transparency, mechanical stability, suture retention, that ultimately govern long‐term stromal ...
Shadi Moshayedi, Ashley Vazquez, Alexander J. Choi, Dimitrios Karamichos, Jayoung Kim   +4 more
wiley   +1 more source

A presentation of posterior reversible encephalopathy syndrome after heart transplantation: a case report and review of literature

Journal of Medical Case Reports
Background Posterior reversible encephalopathy syndrome is a rare disorder encompassing multiple neurological symptoms usually corroborated by specific neuro magnetic resonance imaging features.
Daniel Grandmougin, Tristan Ehrlich, Yihua Liu, Juliette Piccoli, Pan Dan, Elodie Phamisith, Francesco Ferraro, Cristina Sirbu, Irina Klemina, Emmanuelle Schmitt, Ismaël Yahia, Michael Massin, Benjamin Lefèvre, Carine Thivilier, Fabrice Vanhuyse, Stéphane Zuily, Juan-Pablo Maureira   +16 more
doaj   +1 more source

Management of Tacrolimus-induced thrombotic microangiopathy in a heart transplant recipient: Utilizing novel immunosuppression strategies

JHLT Open
Thrombotic microangiopathy (TMA) represents a heterogeneous group of disorders characterized by endothelial injury, complement activation, and platelet aggregation, and may occur in association with systemic diseases, infections, or drug exposure.
Petra Girandon Sušanj, MD, Renata Okrajšek, MD, PhD, Sabina Frljak, MD, PhD, Gregor Zemljič, MD, PhD, Andraž Cerar, MD, PhD, Miran Šebeštjen, MD, PhD, Sabina Ugovšek, MD, Tine Bajec, MD, Gregor Poglajen, MD, PhD   +8 more
doaj   +1 more source

Types and Structure of Complications, and Causes of Mortality with Different Combinations of Immunosuppressants in Patients of Undergoing Organ Transplantation

Heart Vessels and Transplantation, 2017
We aimed to retrospectively analyze morbidity and mortality in recipients of kidney and liver transplant receiving immunosuppressive therapy (tacrolimus and cyclosporine with mycophenolate mofetil and mycophenolic acid).
Jamalbek I. Ashimov, Janybek J. Gaibyldaev   +1 more
doaj   +1 more source