Results 161 to 170 of about 2,071,977 (304)

Beyond Histocompatibility: Donor Tissue Immune States and Their Role in Heart Transplantation. [PDF]

Int J Mol Sci
Urbanowicz T, Kowalewski M, Suwalski P, Raffa GM.   +3 more
europepmc   +1 more source

HOMOVITAL TRANSPLANTATION OF THE HEART

The Journal of Thoracic and Cardiovascular Surgery, 1961
R R, LOWER, R C, STOFER, N E, SHUMWAY
openaire   +2 more sources

Alkylating Agent–Induced FANCL Impairment Damages Pulmonary Arterial, Venous, and Microvascular Endothelial Cells and Predisposes to PAH/PVOD

Advanced Science, EarlyView.
This study establishes a novel cisplatin‐induced rat model of PAH/PVOD and identifies a conserved mechanistic axis—FANCL impairment, DNA damage accumulation, and endothelial dysfunction—triggered by cisplatin or mitomycin C across pulmonary arteries, veins, and microvessels.
Shiyun Liu, Yufei Sun, Xinlei Wu, Haixia Chen, Shaocong Mo, Zichong Li, Yiwei Gong, Xiaoqian Shan, Yuanqi Li, Yaru Guan, Junqi Zhu, Han Yan, Min Du, Feng Wei, Peixin Ou, Ziyi Wang, Chenting Zhang, Lei Xu, Wenju Lu, Jian Wang, Kai Yang   +20 more
wiley   +1 more source

Post-heart transplantation immunosuppression and rejection: what the general cardiologist needs to know. [PDF]

Heart
Jain R, Kittleson MM.
europepmc   +1 more source

CD112 Lactylation Drives Dual Immune Evasion From CD8+ T Cells and NK Cells

Advanced Science, EarlyView.
AARS2 functions as an intracellular lactate sensor and lactyltransferase, catalyzing CD112 K412 lactylation to block ubiquitination‐dependent degradation and stabilize CD112. This pathway suppresses CD8+ T‐cell and NK‐cell cytotoxicity, enabling dual immune evasion.
Zhuoshuo Xu, Xinyu Zhang, Fang Dong, Nenghao Shen, Jun Zhou, Zihan Xi, Zhenghao Wu   +6 more
wiley   +1 more source

Redox Phenotyping of the Donor Heart: A New Paradigm for Precision Heart Transplantation. [PDF]

Antioxidants (Basel)
Urbanowicz T, Kowalewski M, Raffa GM, Krasińska B, Pisano C, Nuzzi V, Rahnama M, Suwalski P, Krasiński Z, Grywalska E.   +9 more
europepmc   +1 more source

Digoxin Alleviates Osteoarthritis by Inhibiting Macrophage Extracellular Trap Formation via Disruption of the LSP1‐SOD1 Interaction

Advanced Science, EarlyView.
Synovial macrophages in osteoarthritis upregulate LSP1, which directly binds and inhibits SOD1, triggering a redox imbalance that activates both NOX and mitochondrial ROS pathways. This cascade drives the release of macrophage extracellular traps (METs), causing chondrocyte damage and disease progression.
Yankai Pan, Xinzhe Feng, Chuanju Liu, Jianfei Tong, Zhi Li, Chenxu Liu, Yutong Dong, Chen Meng, Yihong Xu, Weidong Xu   +9 more
wiley   +1 more source

Checkpoint‐Directed Glycoengineering Reprograms the Vascular Lumen for Siglec‐Mediated Immune Regulation

Advanced Science, EarlyView.
Checkpoint‐directed glycoengineering installs sialylated ligands on the donor vascular lumen during ex vivo preservation, creating a localized Siglec‐7/9‐engaging interface. The engineered glycocalyx suppresses immune‐cell activation, complement deposition, and microvascular injury in arterial and kidney allografts while preserving endothelial ...
Md Mohosin Rana, Javairia F. Rahim, Aaron P. Bernstein, Peyman Malek Mohammadi Nouri, Lyann Sim, Winnie Enns, Jenice M. Dumlao, Haiming D. Luo, Irina Chafeeva, Hong‐Ming Chen, Aizhou Wang, Jiao‐Jing Wang, Edward N. Schmidt, Zheng Jenny Zhang, Marcelo Cypel, Christopher Nguan, Matthew S. Macauley, Stephen G. Withers, Jonathan C. Choy, Jayachandran N. Kizhakkedathu   +19 more
wiley   +1 more source

Preliminary experience with controlled hypothermic storage of donor heart in combined heart transplantation. [PDF]

JHLT Open
Argaw ST, Lora Ronco L, Frering A, Kloeckner M, Coutance G, Coilly A, Vibert E, Snanoudj R, Genty T, Achouh P, Belli E, Guihaire J.   +11 more
europepmc   +1 more source

Situs inversus donor heart successfully transplanted

, 1998
Orthotopic heart transplantation was successfully performed in a 62-year-old man by use of a heart harvested from a donor with situs inversus. This procedure is a reasonable alternative when no other donor is available. The technique of this operation is
Tkebuchava, T., Kunzli, A., von Segesser, L. K., Turina, M.   +3 more
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